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RecruitingNCT05783869Updated Nov 3, 2026

Study of Bronchiectasis and Associated Cardiovascular Comorbidities

An observational study in Bronchiectasis, sponsored by Assiut University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-11-03.

Sponsored by Assiut University · Observational

From the registry’s dates

  • Started Mar 2023; still recruiting 3 years 7 months later.
Updated Nov 3, 2026Primary completion movedStudy completion movedGo to Updates ↓
Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
30
Ages
18 Years to 80 Years
Sex
All
01

Study summary

Effect of cardiovascular comorbidities on disease severity and quality of life in Patients with acute exacerbation of non-cystic fibrosis bronchiectasis

Read the detailed description

The study will include patients with bronchiectasis, and in an attempt to correlate the effect and burden of cardiovascular comorbidities in those patients, we will study the quality of life in those patients in comparison to the control group ( patients with bronchiectasis and without any other comorbidities) using SF-36 quality of life questionnaire. We will also study the inflammatory markers in both groups using D-dimer, BNP, and CRP and correlate them with the frequency of hospital admission, the severity of symptoms, and the general health state.

02

Conditions studied

  • Bronchiectasis

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03

In context

Bronchiectasis

404 studies on the registry are indexed under Bronchiectasis; 125 are open to participants now.

This study's planned enrollment of 30 is below the median of 160 across 137 observational studies indexed under Bronchiectasis.

Browse Bronchiectasis studies →

Lead sponsor

Assiut University is the lead sponsor of 5,078 studies on the registry; 2,178 are open to participants now.

Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

all patients at the study period attending the chest department at Assuit university

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Any Patients with Bronchiectasis had no comorbidities other than cardiovascular comorbidities during the study period.

Exclusion criteria

Exclusion Criteria:

  • Any Patients who refuse to participate in the study.
  • Any other comorbidity or end-organ failure may affect the study's result.
05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
30 participants (estimated)
Patient registry
No

Groups and cohorts

  • Patient with bronchiectasis and cardiovascular comorbidities

    Patients with Bronchiectasis had no comorbidities other than cardiovascular comorbidities during the study period.

    Device: Echocardiography

  • Patients with bronchiectasis and without cardiovascular comorbidities

    Patients with Bronchiectasis had no comorbidities.

    Device: Echocardiography

Interventions

  • DeviceEchocardiography

    echocardiographic study of both groups

    Also known as: Pulmonary function test, Routine laboratory investigations and inflammatory markers

06

What researchers measure

Primary outcomes

  1. assessment of BNP (Brain natriuretic peptide) pg/ml levels in patients with bronchiectasis and cardiovascular comorbidities.

    Serum BNP (Brain natriuretic peptide) pg/ml will be compared in both groups.

    Time frame: March 2023 to September 2023

  2. Assessment of Quality of life in patients and control groups using The Short Form (36) Health Survey (SF-36)

    The Short Form (36) Health Survey will be performed in both groups. The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. The lower the score the more disability. The higher the score the less disability i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability.

    Time frame: March 2023 to September 2023

Secondary outcomes

  1. Hospitalization frequency in patient group compared to control group.

    Number of hospital admission in the last year will be compared in both groups.

    Time frame: March 2023 to September 2023

07

Study locations

1 of 1 sites recruiting
  • Assiut unviresty - Faculty of Medicine
    Asyut, 71511, Egypt
    Recruiting
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it moved

Started Mar 2023 (actual). Primary completion is estimated for Dec 2026, 45 months after the start.

Since we started tracking on Sep 25, 2026, the dates moved once, on Nov 3, 2026: primary completion Sep 2026 → Dec 2026 and completion Nov 2026 → Feb 2027.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Feb 12, 2023
First posted
Mar 24, 2023
StartActual
Mar 25, 2023
Primary completionEst.
Dec 30, 2026was Sep 2026
CompletionEst.
Feb 2, 2027was Nov 2026
Last update
Nov 3, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Primary completion
Sep 1, 2026→Dec 30, 2026
Nov 3, 2026
Study completion
Nov 2, 2026→Feb 2, 2027
Nov 3, 2026
Show all 1 update
  1. Nov 3, 2026
    Primary completion Sep 1, 2026→Dec 30, 2026
    Study completion Nov 2, 2026→Feb 2, 2027
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT05783869
Lead sponsor
Assiut University
Collaborators
Aliae AR Mohamed Hussein [ahussein
Responsible party
Ahmad Shaddad (Lecturer of pulmonary medicine Assuit university, Assiut University) — Principal investigator
First posted
Mar 24, 2023
Start date
Mar 25, 2023
Primary completion
Dec 30, 2026 (estimated)
Completion
Feb 2, 2027 (estimated)
Last update
Nov 3, 2026

Study contacts

Shaadad Shaddad, MD
Contact
shaddad_ahmad@yahoo.com
+201111171930
Ahmad Shaddad, MD
Contact
shaddad_ahmad@yahoo.com
+201111171930
Ahmad Shaddad
principal investigator · Assuit University Faculty of Medicine
Ahmad Shaddad
principal investigator · Assiut University Faculty of Medicine

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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