An interventional study of Periodontal surgery with CAF+tSCTG and Periodontal surgery with CAF+L-PRF in Gingival Recession, sponsored by G. d'Annunzio University. Completed at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-11-21.
Sponsored by G. d'Annunzio University · Not applicable, Interventional, and Treatment
The aim of the present randomized controlled clinical study is to compare the efficacy of subepithelial connective tissue graft harvested from the maxillary retromolar tubeosity area and L-PRF membranes in the treatment of RT1 recessions by coronally advanced flap.
A total of 30 patients will be recruited and randomly assigned to the test group treated with CAF+tSCTG or the control group treated with (CAF+L-PRF). For each experimental site the parameters of gingival recession (GR), pocket depth (PD), clinical attachment level (CAL), keratinized gingiva width (KT) and gingival thickness (GT) will be analyzed at baseline (T0) and at 12 months after the surgical procedure (T1). In addition, was also evaluated the different morbidity of the two surgical techniques, using the VAS scale values recorded in the first 2 weeks following surgery. It was checked the Patient Related Esthetic Score and Dentine hypersensivite reduction.
402 studies on the registry are indexed under Gingival Recession; 98 are open to participants now.
This study's enrollment of 30 is close to the median of 30 across 368 interventional studies indexed under Gingival Recession.
Browse Gingival Recession studies →G. d'Annunzio University is the lead sponsor of 62 studies on the registry; 21 are open to participants now.
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Inclusion Criteria:
15 sites will be treated.The extent of the depth of the recession will be reported on the anatomical papillae and, after adding 1 mm, 2 horizontal incisions of approximately 3 mm will be made at the base of the surgical papillae laterally to the recession.Two divergent releasing incisions will be made extending approximately 2-3 mm into the alveolar mucosa.The surgical papillae will be detached in partial thickness. A full thickness dissection will be performed from the bottom of the recession to expose approximately 3mm of the crest bone.A partial thickness dissection will be performed in the most apical portion of the flap until complete passivation of the flap is obtained.The harvesting of the epithelial-connective graft will be performed at the level of the maxillary tuberosity. The de-epithelialised graft will be sutured at the level of the de-epithelialised anatomical papillae.The flap will be repositioned coronally suturing the anatomical papillae on the surgical ones.
Procedure: Periodontal surgery with CAF+tSCTG
15 sites will be treated.The extent of the depth of the recession will be reported on the anatomical papillae and, after adding 1 mm,2 horizontal incisions of approximately 3 mm will be made at the base of the surgical papillae laterally to the recession. Two divergent releasing incisions will be made extending approximately 2-3 mm into the alveolar mucosa. The surgical papillae will be detached in partial thickness. A full thickness dissection will be performed from the bottom of the recession to expose approximately 3mm of bone.A partial thickness dissection will be performed in the apical portion of the flap to obtain complete passivation.The L-PRF membranes will be realized centrifuged venous blood collected in two 10-ml sterile tubes at 3000 rpm for 10 minutes and squeezing the fibrin clot. L-PRF membranes will be superimposed to crete a double layer of about 2 mm thickness.The flap will be repositioned coronally suturing the anatomical papillae on the surgical ones.
Procedure: Periodontal surgery with CAF+L-PRF
Coronally advanced flap and subepithelial connective tissue graft harvested from the maxillary tuberosity area.
Coronally advanced flap and L-PRF membranes
Gingival thickness
Gingival tissue thickness 2 mm apical to the recession
Time frame: 12 months
Keratinized tissue height
Distance between gingival margin and Mucogingival Junction
Time frame: 12 months
Gingival recession
Distance from cementoenamel junction and gingival margin
Time frame: 12 months
Complete root coverage
Percentage of experimental sites that achieved complete root surface coverage.
Time frame: 12 months
Clinical attachment level
Distance between cementoenamel junction(CEJ) and depth of the pocket
Time frame: 12 months
Pocket depth
Distance between gingival margin and bottom of the pocket
Time frame: 12 months
Plan to share: No
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This study is completed, as verified in Nov 2023. You cannot join it, but the record below documents what was studied.
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G. d'Annunzio University