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CompletedNCT05692791Updated Jul 26, 2024

Idiopathic Toe-Walking Position Sensation

An observational study in Gait Disorder, Sensorimotor, sponsored by Kirsehir Ahi Evran Universitesi. Completed at 1 site in Turkey. Open to participants aged 3 Years to 10 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-07-26.

Sponsored by Kirsehir Ahi Evran Universitesi · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
94
Ages
3 Years to 10 Years
Sex
All
01

Study summary

The aim of this study is to investigate the effect of plantar two-point discrimination on hip-knee-ankle position sense in children with toe walking.The main questions it aims to answer are:

  • Are two-point discrimination and light pressure sensation in the plantar region affected in children with idiopathic toe gait?
  • Does the two-point discrimination in the plantar in general and the heel in particular affect the position sense of the hip-knee and ankle?
Read the detailed description

Children who tend to walk on toes after they should have developed a heel-toe gait are diagnosed with idiopathic toe walking (ITW).Cerebral palsy, muscular dystrophy, and orthopaedic problems such congenital talipes equinus are some of the diseases that are frequently linked to a toe-walking gait. A diagnosis of ITW is made when there is no physical or medical cause for the absence of a heel strike. Five percent of healthy children are estimated to have ITW, and boys are more likely than girls to be affected. Reduced ankle range of motion is prevalent symptom in children with ITW. Since ITW often manifests as symmetrical tiptoe walking in children, reports showing a comparable bilateral reduction in ankle range of motion at both lower limbs indicate the symmetrical character of this gait type. Lower vibration perception thresholds, a tendency to be left-handed, and noticeable variations in sensory seeking and modulation scores are all characteristics of children with an ITW gait.

The small fibers that innervate the cutaneous receptors (such as Merkel's cell, Pacinian corpuscles, Meissner's corpuscles, and Ruffini endings in the skin) are more crucial for postural control than the large fibers that innervate the major muscle spindles and the Golgi tendon organs. Standing balance control is more dependent on Merkel's cells and Ruffini endings (slow adapting receptors), which are in charge of touch and pressure sensitivity, than it is on Meissner's and Pacinian corpuscles (rapid adapting receptors), which are in charge of vibrotactile sensitivity.Additionally, it has been demonstrated that tactile sensation in the foot sole affects the activity of the tibialis anterior muscle as well as the regulation of gait pattern at lower limb joints. These investigations support the notion that cutaneous feeling is crucial for preserving postural and gait stability.The literature states that plantar pressure and sensory changes have disruptive effects on postural control.The aim of this study is to investigate the effect of plantar two-point discrimination on hip-knee-ankle position sense in children with toe walking.

02

Conditions studied

  • Gait Disorder, Sensorimotor

Keywords

  • Idiopathic Toe Walking
03

In context

Gait Disorders, Neurologic

327 studies on the registry are indexed under Gait Disorders, Neurologic; 54 are open to participants now.

This study's enrollment of 94 is above the median of 54 across 75 observational studies indexed under Gait Disorders, Neurologic.

Browse Gait Disorders, Neurologic studies →

Lead sponsor

Kirsehir Ahi Evran Universitesi is the lead sponsor of 133 studies on the registry; 55 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
3 Years to 10 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Children who have idiopathic toe walking in the experimental group and healthy children in the control group with the same ages.

Inclusion criteria

  • Having idiopathic toe walking diagnosis

Exclusion criteria

Exclusion Criteria:

  • Having another known neuromuscular disease
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
94 participants (actual)
Patient registry
No

Groups and cohorts

  • ITW

    Diagnostic Test: Two-point Discrimination Test · Diagnostic Test: Semmes-Weinstein monofilament test

  • Control Group

    Diagnostic Test: Two-point Discrimination Test · Diagnostic Test: Semmes-Weinstein monofilament test

Interventions

  • Diagnostic testTwo-point Discrimination Test

    Two-point discrimination (2PD) is the ability to discern that two nearby objects touching the skin are truly two distinct points, not one. It is often tested with two sharp points during a neurological examination and is assumed to reflect how finely innervated an area of skin is.

  • Diagnostic testSemmes-Weinstein monofilament test

    Semmes-Weinstein monofilament test is used to assess light touch sensations.

06

What researchers measure

Primary outcomes

  1. Hip-Knee-Ankle Joint Position Sense

    Position the body segment being tested and then passively position the individual's joint in space. Hold the lateral surfaces of the limb to minimize cues from touch and pressure sensations. Move the body segment into a position and either have the patient maintain the position or assist the patient in maintaining the position if needed. Have the patient duplicate the position with the opposite extremity. The procedure is repeated enough times to conclude if joint position sense is intact or impaired. A suggested minimum number of trials is five per joint.

    Time frame: 15 weeks

07

Study locations

1 site
  • Ahi Evran University
    Kırşehir, Turkey
08

References and documents

Publications

  • Silva PG, Jones A, Araujo PM, Natour J. Assessment of light touch sensation in the hands of systemic sclerosis patients. Clinics (Sao Paulo). 2014 Sep;69(9):585-8. doi: 10.6061/clinics/2014(09)02. PubMed 25318088 ↗
  • Westberry DE, Davids JR, Davis RB, de Morais Filho MC. Idiopathic toe walking: a kinematic and kinetic profile. J Pediatr Orthop. 2008 Apr-May;28(3):352-8. doi: 10.1097/BPO.0b013e318168d996. PubMed 18362803 ↗

Individual participant data

Plan to share: Yes — With mail

Supporting information: Study protocol, Sap, Icf, Csr

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 26, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05692791
Lead sponsor
Kirsehir Ahi Evran Universitesi
Responsible party
Ömer Faruk ÖZÇELEP (Lecturer, Kirsehir Ahi Evran Universitesi) — Principal investigator
First posted
Jan 20, 2023
Start date
Apr 30, 2024
Primary completion
Jun 25, 2024
Completion
Jun 25, 2024
Last update
Jul 26, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.

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