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Status unknownNCT05678049Updated Jan 10, 2023

Evaluation and Characterisation of Microplastics and Nanoplastics in Joint Synovial Liquid

An observational study in Osteoarthritis, Knee, Knee Arthritis and Gout Arthritis, sponsored by Iuliu Hatieganu University of Medicine and Pharmacy. Status unknown. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2023-01-10.

Sponsored by Iuliu Hatieganu University of Medicine and Pharmacy · Observational

The sponsor has not verified this record recently (last verified Jan 2023), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
50
Ages
18 Years to 90 Years
Sex
All
01

Study summary

The research study aims to evaluate the synovial fluid to highlight the presence of possible micropolymers (micro/nanoplastics) in order to better understand the pathophysiology of joint degenerative processes. For patients with liquid under tension at the joint level, the symptomatology often requires evacuation by puncture under ultrasound guidance. The intervention will be performed only for patients for whom this therapeutic indication exists anyway by their physician.

The investigators want to use this liquid for Microscopic and Spectrophotometric evaluation.

02

Conditions studied

  • Osteoarthritis, Knee
  • Knee Arthritis
  • Gout Arthritis
  • Microcrystal Disease
03

In context

Osteoarthritis, Knee

3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.

This study's planned enrollment of 50 is below the median of 100 across 486 observational studies indexed under Osteoarthritis, Knee.

Browse Osteoarthritis, Knee studies →

Lead sponsor

Iuliu Hatieganu University of Medicine and Pharmacy is the lead sponsor of 56 studies on the registry; 15 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Inpatients on a Rehab Department with arthritis of the knee that require evacuation of the knee joint

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • arthritis of the knee with liquid aspiration recommendation
  • age >18 years

Exclusion criteria

Exclusion Criteria:

--refusal of the patient to participate

-age\<18 years

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
50 participants (estimated)
Patient registry
No

Interventions

  • Diagnostic testSynovial fluid analysis

    For patients with knee under tension at the joint level, the symptomatology often requires evacuation by puncture under ultrasound guidance. The intervention will be performed only for patients for whom this therapeutic indication exists anyway by their physicians. After making the evacuation we will want to use this liquid for Microscopic and Spectrophotometric evaluation

06

What researchers measure

Primary outcomes

  1. microplastics

    evaluation with spectrophotometry and optic microscopy

    Time frame: immediately after liquid extraction

  2. nanoplastics

    evaluation with spectrophotometry and optic microscopy

    Time frame: immediately after liquid extraction

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 10, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT05678049
Lead sponsor
Iuliu Hatieganu University of Medicine and Pharmacy
Responsible party
Ciubean Alina Deniza (Director, Iuliu Hatieganu University of Medicine and Pharmacy) — Principal investigator
First posted
Jan 10, 2023
Start date
Jan 15, 2023 (estimated)
Primary completion
Dec 15, 2023 (estimated)
Completion
Dec 15, 2024 (estimated)
Last update
Jan 10, 2023

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2023. You cannot join it, but the record below documents what was studied.

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