An interventional study of Computerized cognitive program in Metabolic Syndrome and Cognitive Deficit, sponsored by University of Ioannina. Completed at 1 site in Greece. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-07-02.
Sponsored by University of Ioannina · Not applicable, Interventional, and Supportive care
The goal of this clinical trial is to investigate the possibility of rehabilitation of mild cognitive deficits in people with metabolic syndrome. We aim to implement a cognitive training program on patients with metabolic syndrome and cognitive deficits, and examine its effectiveness both post-intervention (3 months) and after 12 months.
Researchers will compare two groups, the experimental group that will receive the computerized cognitive training and the control group that will receive no training.
1,964 studies on the registry are indexed under Metabolic Syndrome; 330 are open to participants now.
This study's enrollment of 50 is below the median of 60 across 1,460 interventional studies indexed under Metabolic Syndrome.
Browse Metabolic Syndrome studies →University of Ioannina is the lead sponsor of 53 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
25 participants with metabolic syndrome and mild cognitive deficits; receive health advice using the World Health Organization's guidelines for Risk Reduction of Cognitive Decline and Dementia, and perform the computerized cognitive training program (BrainHQ) for 45 minutes per session, twice per week, over the 3-month intervention period.
Other: Computerized cognitive program
25 participants with metabolic syndrome and mild cognitive deficits; receive health advice using the World Health Organization's guidelines for Risk Reduction of Cognitive Decline and Dementia.
BrainHQ was developed by Posit Science and includes computer-based brain-training exercises organized into six categories: Attention, Brain Speed, Memory, People Skills, Intelligence, and Navigation. Participants were instructed to perform a total of 24 sessions of computerized cognitive training at home, consisting of 45 minutes of training, twice per week, over a 3-month period.
Change in scores of the Montreal Cognitive Assessment (MoCA) test
MoCA is a screening test for mild cognitive dysfunction; range 0-30, higher scores represent better cognitive function
Time frame: baseline, post-intervention (3 months), follow-up (1 year from baseline)
Change in scores of Complex Figure tests
Complex Figures assess visuo-constructional ability and visual memory; range 0-36, higher scores represent better cognitive function
Time frame: baseline, post-intervention (3 months), follow-up (1 year from baseline)
Change in scores of Hopkins Verbal Learning Test-Revised (HVLT-R)
HVLT-R assesses verbal memory using a list of words; range 0-36 (immediate recall) and range 0-12 (delayed recall), higher scores represent better cognitive function
Time frame: baseline, post-intervention (3 months), follow-up (1 year from baseline)
Change in scores of Digit Span test
Digit Span assesses working memory; range 0-14 (performance) and range 2-9 (span) for forward and backward condition, higher scores represent better cognitive function
Time frame: baseline, post-intervention (3 months), follow-up (1 year from baseline)
Change in scores of semantic Verbal Fluency test
Verbal Fluency assesses executive function that also relies on language component; higher scores represent better cognitive function
Time frame: baseline, post-intervention (3 months), follow-up (1 year from baseline)
Change in scores of Flanker task
Flanker task assesses executive function and inhibition; range 0-48, higher scores represent better cognitive function
Time frame: baseline, post-intervention (3 months), follow-up (1 year from baseline)
Change in scores of Continuous Performance Test (CPT)
CPT assesses executive function and inhibition; range 0-100, higher scores represent better cognitive function
Time frame: baseline, post-intervention (3 months), follow-up (1 year from baseline)
Change in scores of Set Shifting
Set Shifting assesses executive function and set-shifting; range 0-104, higher scores represent better cognitive function
Time frame: baseline, post-intervention (3 months), follow-up (1 year from baseline)
Change in scores of N-back
N-back assesses working memory; range 0-30, higher scores represent better cognitive function
Time frame: baseline, post-intervention (3 months), follow-up (1 year from baseline)
Change in scores of Everyday Cognition-II (Ecog-II)
Ecog-II is a measure of everyday functioning that includes 41 items to assess memory, language, visual, spatial and perceptual abilities, planning, organization, and divided attention; higher scores represent worse everyday functioning
Time frame: baseline, follow-up (1 year from baseline)
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Ioannina