A Phase 4 interventional study of Remimazolam and Propofol in Remimazolam, Propofol and Orthopedic Procedures, sponsored by Asan Medical Center. Completed at 1 site in Korea, Republic of. Open to participants aged 20 Years to 64 Years. Per ClinicalTrials.gov, last updated 2025-02-26.
Sponsored by Asan Medical Center · Phase 4, Interventional, and Treatment
The purpose of this study is to compare the incidence of hypotension between remimazolam and propofol for intraoperative sedation in patients undergoing hip surgery with spinal anesthesia.
1,003 studies on the registry are indexed under Hypotension; 173 are open to participants now.
This study's enrollment of 78 is close to the median of 80 across 675 interventional studies indexed under Hypotension.
Browse Hypotension studies →Asan Medical Center is the lead sponsor of 562 studies on the registry; 71 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
A maintenance dose of remimazolam is administered for sedation
Drug: Remimazolam
A maintenance dose of propofol is administered for sedation
Drug: Propofol
Patients receive remimazolam at a rate of 1 mg/kg/hr. When a patient's MOAA/S reaches 3 or less, the rate of remomazolam is maintained at a rate between 0.3 mg/kr/hr and 1.0 mg/kg/hr until the end of surgery.
Patients are administered propofol with an effect-site concentration of 1.0 mcg/mL to 2.5 mcg/mL by target controlled infusion.
Frequency of hypotension during surgery (1hour)
mean blood pressure less than 65mmHg
Time frame: up to 1 hour after initiation of drug infusion
Frequency of hypotension during surgery
mean blood pressure less than 65mmHg
Time frame: Throughout the surgery
Total administered phenylephrine
total dose of phenylephrine administered during surgery
Time frame: Throughout the surgery
Fluid volume
Total amount of fluid infused during surgery
Time frame: Throughout the surgery
Number of hypotensive episodes in the post-anesthesia care unit after surgery
mean blood pressure less than 65mmHg
Time frame: up to 1 hour after postanesthesia care unit entry
Complications after surgery
Cardiovascular/neurological/respiratory complications, delirium, impaired renal function, or postoperative nausea and vomiting
Time frame: up to 7 days after surgery
This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Asan Medical Center