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CompletedNCT05620992Updated Oct 28, 2026

Evaluation of Right Ventricular Function Post Mitral Valve Operations

An observational study in Right Ventricular Dysfunction, sponsored by Assiut University. Completed at 1 site in Egypt. Per ClinicalTrials.gov, last updated 2026-10-28.

Sponsored by Assiut University · Observational

Updated Oct 28, 2026Now CompletedFirst site in Egypt+5 moreGo to Updates ↓
Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
50
Sex
All
01

Study summary

We aim to determine the function of Right ventricle post mitral valve surgeries in patients with pulmonary hypertension using transthoracic echocardiography3- and 6-months post-operatively to detect the effect of mitral valve surgeries over the RV function whether improving, deteriorating, or not changing at all.

02

Conditions studied

  • Right Ventricular Dysfunction
03

In context

Ventricular Dysfunction, Right

90 studies on the registry are indexed under Ventricular Dysfunction, Right; 28 are open to participants now.

This study's enrollment of 50 is below the median of 100 across 51 observational studies indexed under Ventricular Dysfunction, Right.

Browse Ventricular Dysfunction, Right studies →

Lead sponsor

Assiut University is the lead sponsor of 5,078 studies on the registry; 2,178 are open to participants now.

Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Browse Assiut University studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

The criteria were revised on the registry on Oct 28, 2026. See what changed

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Descriptive cross-sectional

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients who underwent mitral valve surgeries who also had pulmonary hypertension in the period between March 2019 and March 2023 in Assiut university heart hospital

Exclusion criteria

Exclusion Criteria:

  • Patients who underwent mitral valve surgeries with normal pulmonary pressure. Patients who had other valve surgeries besides mitral as aortic and/or tricuspid valve surgeries. Patients had mitral valve surgeries with other heart conditions that needed another intervention in the same session as CABG for IHD.
05

Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
50 participants (actual)
Patient registry
No

Interventions

  • DeviceEchocardiography

    Echocardiography 3 and 6 months post operative

06

What researchers measure

Primary outcomes

  1. Right Ventricular function post mitral valve surgeries in patients with pulmonary hypertension

    to detect right ventricular function (ejection fraction percentage and/or TAPSE) through transthoracic echocardiography 3- and 6-months post operatively in patients who had mitral valve surgeries with pulmonary hypertension.

    Time frame: From March 2019 till March 2022

Secondary outcomes

  1. Best mitral valve surgical modalities in patients with pulmonary hypertension

    to identify best surgical modalities for mitral valve diseased patients with pulmonary hypertension that lead to improvement of right ventricle function.

    Time frame: From March 2019 till March 2022

07

Study locations

1 site
  • Assiut Heart University Hospital
    Asyut, Egypt
08

References and documents

Publications

  • Ho SY. Anatomy of the mitral valve. Heart. 2002 Nov;88 Suppl 4(Suppl 4):iv5-10. doi: 10.1136/heart.88.suppl_4.iv5. No abstract available. PubMed 12369589 ↗
  • Tokodi M, Nemeth E, Lakatos BK, Kispal E, Toser Z, Staub L, Racz K, Soltesz A, Szigeti S, Varga T, Gal J, Merkely B, Kovacs A. Right ventricular mechanical pattern in patients undergoing mitral valve surgery: a predictor of post-operative dysfunction? ESC Heart Fail. 2020 Jun;7(3):1246-1256. doi: 10.1002/ehf2.12682. Epub 2020 Mar 26. PubMed 32220010 ↗
  • Denault A, Deschamps A, Tardif JC, Lambert J, Perrault L. Pulmonary hypertension in cardiac surgery. Curr Cardiol Rev. 2010 Feb;6(1):1-14. doi: 10.2174/157340310790231671. PubMed 21286273 ↗
  • Estrada VH, Franco DL, Moreno AA, Gambasica JA, Nunez CC. Postoperative Right Ventricular Failure in Cardiac Surgery. Cardiol Res. 2016 Dec;7(6):185-195. doi: 10.14740/cr500e. Epub 2016 Dec 31. PubMed 28197291 ↗
  • Nagel E, Stuber M, Hess OM. Importance of the right ventricle in valvular heart disease. Eur Heart J. 1996 Jun;17(6):829-36. doi: 10.1093/oxfordjournals.eurheartj.a014963. PubMed 8781821 ↗
09

Updates

1 registry update since Sep 25, 2026
Status
Not yet recruiting→Completed
changed Oct 28, 2026
Sites
1 site added — first site in Egypt
Show site
  • Assiut Heart University Hospital · Asyut, Egypt
Oct 28, 2026
Primary completion
Nov 1, 2025→Dec 1, 2024 (actual)
Oct 28, 2026
Study completion
Nov 1, 2026→Dec 15, 2024 (actual)
Oct 28, 2026
Eligibility
1 inclusion criterion edited
What changed in the criteria
Inclusion criteria
  • EditedPatients who underwent mitral valve surgeries who also had pulmonary hypertension in the period between March 2019 and March 20222023 in Assiut university heart hospital
Oct 28, 2026
Show all 1 update
  1. Oct 28, 2026
    Not yet recruiting→Completed
    1 site added — first site in Egypt
    Show site
    • Assiut Heart University Hospital · Asyut, Egypt
    Primary completion Nov 1, 2025→Dec 1, 2024 (now actual)
    Study completion Nov 1, 2026→Dec 15, 2024 (now actual)
    Eligibility 1 inclusion criterion edited
    What changed in the criteria
    Inclusion criteria
    • EditedPatients who underwent mitral valve surgeries who also had pulmonary hypertension in the period between March 2019 and March 20222023 in Assiut university heart hospital
    + 3 other changes: verification date, design details and index terms

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT05620992
Lead sponsor
Assiut University
Responsible party
Mohammad Ali Mohammad Abdelbakey (Resident, Assiut University) — Principal investigator
First posted
Nov 17, 2022
Start date
Mar 1, 2023
Primary completion
Dec 1, 2024
Completion
Dec 15, 2024
Last update
Oct 28, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.

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Discussion

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