An interventional study of 4 Corners Rural Health Cancer Prevention in Cancer, sponsored by Klein Buendel, Inc.. Active, not recruiting at 5 sites in United States. Open to participants aged 18 Years to 26 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-19.
Sponsored by Klein Buendel, Inc. · Not applicable, Interventional, and Prevention
Young adults aged 18-26 engage in a number of behaviors that increase their risk of developing cancer later in life including sedentary lifestyles, unhealthy eating, nicotine produce us, heavy drinking of alcohol, increased UV exposure, and incomplete uptake of HPV vaccination. A multi-risk factor campaign will be developed to reduce these cancer risk behaviors and delivered to young adults over social media, a popular channel that can reach nearly all young adults. The campaign will be evaluated for effectiveness in a rigorous randomized trial with measures of moderate to vigorous physical activity, healthy eating patterns, nicotine product use, alcohol intake, sunburn prevalence, and HPV vaccination uptake.
Several risk factors are prevalent during early adulthood that can lead to cancer later in life. Emerging adults (EAs) aged 18-26 residing in rural areas of the United States engage in many cancer risk behaviors, especially sedentary lifestyles, poor eating patterns, nicotine product use, excess alcohol intake, infrequent sun protection, and inadequate uptake of the HPV vaccine. This application responds to RFA-CA-20-051, "Social and Behavioral Intervention Research to Address Modifiable Risk Factors for Cancer in Rural Populations." The goal is to improve cancer risk behavioral factors among diverse EAs aged 18-26 living in rural counties in the Four Corners states, a unique, underserved region, using a social media campaign designed with community advisors. EAs, including in rural communities, are heavy consumers of online content, especially over social media, and social media provide responsive, engaging, and low-cost platforms for distributing cancer prevention information with high dissemination potential. But, social media also circulate inaccurate, misleading, and harmful information. The specific aims of this research are to: 1) Develop a social media intervention for diverse EAs in rural communities via a community-engaged process that combines expert advice, user-generated content, and online instruction to communicate about behavioral cancer risks, cancer misinformation, counter marketing, digital and media literacy, and family communication; 2) evaluate the effect of a theory-based social media intervention on moderate to vigorous physical activity (MVPA), healthy eating patterns, nicotine product use, alcohol intake, sunburn prevalence, and HPV vaccination with the diverse population of EAs aged 18-26 in rural counties in AZ, CO, NM, and UT (Four Corners states) recruited from Qualtrics' survey panel and enrolled in a pragmatic randomized trial using a stepped-wedge design in which individual EAs will be randomized to 1 of 4 cohorts and receive the social media feed for varying durations in separate Facebook private groups; 3) test if improvements in EAs' cancer risk knowledge and beliefs, digital and media literacy skills, accurate cancer prevention information, and family communication mediate impact of the social media campaign; and 4) explore whether the impact of the social media campaign differs according to: a) level of EAs' engagement with campaign, b) cancer risk factors, and c) biological sex of the participants (as required by NIH). The research is innovative because it tests a theory-based, multi-risk factor approach to cancer prevention with diverse EAs in rural counties, an under-studied population, in a very popular new media. Social media may reach EAs more than interventions through other community channels (e.g., clinics, schools, and workplaces) and for lower cost in the geographically-dispersed, underserved rural communities in the Mountain West. The overall impact is extremely high because it will aid rural EAs in making informed decisions that reduce cancer risk factors and prevent cancer later in life and help EAs critically evaluate and resist misinformation and marketing that promote cancer risk behaviors.
10,818 studies on the registry are indexed under Neoplasms; 2,324 are open to participants now.
This study's enrollment of 1,796 is above the median of 60 across 7,703 interventional studies indexed under Neoplasms.
Browse Neoplasms studies →Klein Buendel, Inc. is the lead sponsor of 35 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Four separate Facebook groups, which provide information via posts within the private groups about cancer risk factors (e.g. reducing alcohol consumption, tobacco use cessation, increasing physical activity), behavioral skills to reduce them, benefits of, social support for, and ways to reduce social/financial costs of cancer prevention, and advice from health care providers to decrease barriers. Posts will seek to improve self- and response-efficacy and perceived risk, and link cancer prevention to personal goals.
Behavioral: 4 Corners Rural Health Cancer Prevention
Participants, aged 18-26, will join a private Facebook group to participate in the intervention. The group is not viewable to the public, including other Facebook users. Content that focuses on cancer prevention behaviors will be posted twice per day for up to 12 months. Each group will be hosted by a moderator who is responsible for managing the intervention goals and participants' engagement.
Physical Activity
Participants will self-report minutes per week of moderate to vigorous physical activity.
Time frame: Baseline
Physical Activity
Participants will self-report minutes per week of moderate to vigorous physical activity.
Time frame: 3 months
Physical Activity
Participants will self-report minutes per week of moderate to vigorous physical activity.
Time frame: 12 months
Physical Activity
Participants will self-report minutes per week of moderate to vigorous physical activity.
Time frame: 24 months
Diet
Participants will self-report intake per day of fruits, vegetables, whole grains/fiber, added sugars (from sugar-sweetened beverages), and red/processed meats.
Time frame: Baseline
Diet
Participants will self-report intake per day of fruits, vegetables, whole grains/fiber, added sugars (from sugar-sweetened beverages), and red/processed meats.
Time frame: 3 months
Diet
Participants will self-report intake per day of fruits, vegetables, whole grains/fiber, added sugars (from sugar-sweetened beverages), and red/processed meats.
Time frame: 12 months
Diet
Participants will self-report intake per day of fruits, vegetables, whole grains/fiber, added sugars (from sugar-sweetened beverages), and red/processed meats.
Time frame: 24 months
Nicotine Product Use
Participants will self-report tobacco/nicotine use in the past 30 days (every day, some days, not at all).
Time frame: Baseline
Nicotine Product Use
Participants will self-report tobacco/nicotine use in the past 30 days (every day, some days, not at all).
Time frame: 3 months
Nicotine Product Use
Participants will self-report tobacco/nicotine use in the past 30 days (every day, some days, not at all).
Time frame: 12 months
Nicotine Product Use
Participants will self-report tobacco/nicotine use in the past 30 days (every day, some days, not at all).
Time frame: 24 months
Alcohol Intake
Participants self-report consumption of number of alcoholic drinks in the past 30 days.
Time frame: Baseline
Alcohol Intake
Participants self-report consumption of number of alcoholic drinks in the past 30 days.
Time frame: 3 months
Alcohol Intake
Participants self-report consumption of number of alcoholic drinks in the past 30 days.
Time frame: 12 months
Alcohol Intake
Participants self-report consumption of number of alcoholic drinks in the past 30 days.
Time frame: 24 months
Uv Exposure
Participants will self-report number of sunburns.
Time frame: Baseline
Uv Exposure
Participants will self-report number of sunburns.
Time frame: 3 months
Uv Exposure
Participants will self-report number of sunburns.
Time frame: 12 months
Uv Exposure
Participants will self-report number of sunburns.
Time frame: 24 months
HPV Vaccination
Participants will self-report whether or not they have received one or more doses of the HPV vaccine.
Time frame: Baseline
HPV Vaccination
Participants will self-report whether or not they have received one or more doses of the HPV vaccine.
Time frame: 3 months
HPV Vaccination
Participants will self-report whether or not they have received one or more doses of the HPV vaccine.
Time frame: 12 months
HPV Vaccination
Participants will self-report whether or not they have received one or more doses of the HPV vaccine.
Time frame: 24 months
Physical Activity
Participants will self-report number of minutes per week engaging in physical activity to determine if they meet the 150 minutes per week recommendation.
Time frame: Baseline
Physical Activity
Participants will self-report number of minutes per week engaging in physical activity to determine if they meet the 150 minutes per week recommendation.
Time frame: 3 months
Physical Activity
Participants will self-report number of minutes per week engaging in physical activity to determine if they meet the 150 minutes per week recommendation.
Time frame: 12 months
Physical Activity
Participants will self-report number of minutes per week engaging in physical activity to determine if they meet the 150 minutes per week recommendation.
Time frame: 24 months
Diet
Participants will self-report frequency of eating meals away from home/fast food.
Time frame: Baseline
Diet
Participants will self-report frequency of eating meals away from home/fast food.
Time frame: 3 months
Diet
Participants will self-report frequency of eating meals away from home/fast food.
Time frame: 12 months
Diet
Participants will self-report frequency of eating meals away from home/fast food.
Time frame: 24 months
Nicotine Product Use
Participants will self-report tobacco/nicotine use in the past 7 days (every day, some days, not at all).
Time frame: Baseline
Nicotine Product Use
Participants will self-report tobacco/nicotine use in the past 7 days (every day, some days, not at all).
Time frame: 3 months
Nicotine Product Use
Participants will self-report tobacco/nicotine use in the past 7 days (every day, some days, not at all).
Time frame: 12 months
Nicotine Product Use
Participants will self-report tobacco/nicotine use in the past 7 days (every day, some days, not at all).
Time frame: 24 months
Nicotine Product Use
Participants will self-report readiness to quit using a 10 point rating scale (1=no thought of quitting; 10=taking action to quit).
Time frame: Baseline
Nicotine Product Use
Participants will self-report readiness to quit using a 10 point rating scale (1=no thought of quitting; 10=taking action to quit).
Time frame: 3 months
Nicotine Product Use
Participants will self-report readiness to quit using a 10 point rating scale (1=no thought of quitting; 10=taking action to quit).
Time frame: 12 months
Nicotine Product Use
Participants will self-report readiness to quit using a 10 point rating scale (1=no thought of quitting; 10=taking action to quit).
Time frame: 24 months
Alcohol Intake
Participants will self-report number of times binge drinking in the past 30 days.
Time frame: Baseline
Alcohol Intake
Participants will self-report number of times binge drinking in the past 30 days.
Time frame: 3 months
Alcohol Intake
Participants will self-report number of times binge drinking in the past 30 days.
Time frame: 12 months
Alcohol Intake
Participants will self-report number of times binge drinking in the past 30 days.
Time frame: 24 months
UV Exposure
Participants will self-report sun protection behaviors with percent of sun exposure hours using sun protection.
Time frame: Baseline
UV Exposure
Participants will self-report sun protection behaviors with percent of sun exposure hours using sun protection.
Time frame: 3 months
UV Exposure
Participants will self-report sun protection behaviors with percent of sun exposure hours using sun protection.
Time frame: 12 months
UV Exposure
Participants will self-report sun protection behaviors with percent of sun exposure hours using sun protection.
Time frame: 24 months
HPV Vaccination
Participants will self-report if they have completed the series of HPV vaccination by receiving 3 doses of the vaccine.
Time frame: Baseline
HPV Vaccination
Participants will self-report if they have completed the series of HPV vaccination by receiving 3 doses of the vaccine.
Time frame: 3 months
HPV Vaccination
Participants will self-report if they have completed the series of HPV vaccination by receiving 3 doses of the vaccine.
Time frame: 12 months
HPV Vaccination
Participants will self-report if they have completed the series of HPV vaccination by receiving 3 doses of the vaccine.
Time frame: 24 months
Started Apr 2024 (actual). Primary completion is estimated for Mar 2027, 35 months after the start.
Of 75 industry-sponsored interventional studies with no phase under Neoplasms, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 53. This study's planned 35 months is above that.
Counting every sponsor, half of 2,056 studies reached it within 29 months; a quarter within 13 and three quarters within 52.
Neoplasms covers many different conditions, not one, so the studies compared here vary widely. Read these figures as a rough guide.
Since we started tracking on Sep 25, 2026, the dates moved once, on Oct 19, 2026: start Aug 2024 → Apr 2024, primary completion Dec 2026 → Mar 2027 and completion Mar 2027 → Aug 2027.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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