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CompletedNCT05615935Updated Oct 1, 2025Results posted

Experiential HIV Testing Increasing Testing Related Knowledge and Practice, and Reduce Stigma Toward HIV of Nurses.

An interventional study of Experiential HIV Testing in Hiv and HIV Testing, sponsored by National Taiwan University. Completed at 1 site in Taiwan. Open to participants aged 20 Years and older. Per ClinicalTrials.gov, last updated 2025-10-01.

Sponsored by National Taiwan University · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
74
Allocation
Randomized
Ages
20 Years and older
Sex
All
01

Study summary

This is a randomized controlled trial design. The investigators plan to recruit about 60 to 70 emergency department nurses from a medical center in Taipei, Taiwan. After completing the paper consent form, these nurses will be randomly assigned to 2 groups, which are a control group and an experimental group. The pre-test includes the demographic data sheet, HIV testing related knowledge and practice scale, and The Health Care Provider HIV/ AIDS Stigma Scale (HPASS). All nurses will receive a learning material when they finish the pre-test. In addition, the experimental group will be provided a real HIV testing and counselling by a researcher. The post-test will be finished one month later of pre-test in the control group, and one month later while the intervention completed in the experimental group. The semi-structural interview will be performed to the experimental group to collect and analyze their opinion toward the experiential HIV testing.

Read the detailed description

This project aims to develop an intervention of "experiential HIV testing" and to verify the following effects on emergency nurses: (1) Improve HIV testing related knowledge and practice; (2) Reduce HIV-related stigma; (3) Find out the possible demographic factors that might affect the effectiveness of experiential HIV Testing. During the intervention, nurses can directly participate in the whole process of anonymous HIV testing in the role of who need to be screened, and pre- and post-testing counselling accompanied the education and discussion will also be provided to them by a researcher. Through the above-mentioned measures, the knowledge and practices related to the HIV testing could be improved, and the stigma attitude toward HIV could be reduced through the self-reflection on the testing process.

02

Conditions studied

  • Hiv
  • HIV Testing

Keywords

  • stigma
  • knowledge
  • Education, nursing
  • situated learning
03

In context

Acquired Immunodeficiency Syndrome

2,040 studies on the registry are indexed under Acquired Immunodeficiency Syndrome; 272 are open to participants now.

This study's enrollment of 74 is below the median of 105 across 1,543 interventional studies indexed under Acquired Immunodeficiency Syndrome.

Browse Acquired Immunodeficiency Syndrome studies →

Lead sponsor

National Taiwan University is the lead sponsor of 22 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

- have registered nurse license and do clinical care in emergency department

Exclusion criteria

Exclusion Criteria:

  • have registered nurse license but doesn't do clinical care, likes head nurse.
  • do clinical care in emergency department but doesn't have registered nurse license, like volunteers or assistant nurse.
  • have experienced non-occupational HIV testing.
  • had been a nurse in HIV/AIDS-focus ward or HIV/AIDS case manager.
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
74 participants (actual)

Study arms

  • Experimental
    Get a learning material and a experiential HIV Testing

    These participants in the experimental group will be provided a learning material about HIV testing, then an experiential HIV Testing, which includes HIV testing and counselling, education and discussion, and a post-test interviews will be provided.

    Other: Experiential HIV Testing

  • No intervention
    Get a learning material only

    These participants in the control group will be provided a learning material about HIV testing only. After the post-test, the experiential HIV Testing will be provided to them.

Interventions

  • OtherExperiential HIV Testing

    The content of experiential HIV Testing includes HIV testing, counselling, and education and discussion.

06

What researchers measure

Primary outcomes

  1. HIV Testing Related Knowledge and Practice

    A self-development scale, known as the "HIV Testing-Related Knowledge and Practice Scale," is employed to assess individuals' knowledge and practices pertaining to HIV testing. The scale consists of twenty-eight questions, encompassing both True-False and multiple-choice formats. Participants earn one point for each correct answer, contributing to a total score that ranges from the minimum scores of 0 to the maximum scores of 28. Higher scores signify a more positive outcome, indicating enhanced HIV testing-related knowledge and practice among the participants.

    Time frame: pre-test(Baseline) and post-test (week 4)

  2. HIV Related Stigma

    The Healthcare Provider HIV/AIDS Stigma Scale (HPASS) will be used to assess this outcome. The instrument contains 30 items, each scored on a six-point Likert scale, yielding a minimum total score of 30 and a maximum of 180. Higher scores reflect greater levels of stigma toward people living with HIV, indicating a worse outcome. Validation of the HPASS through factor analysis identified three underlying dimensions. The stereotyping dimension (11 items; score range: 11-66) reflects negative cognitions and beliefs about people living with HIV. The prejudice dimension (13 items; score range: 13-78) captures emotionally driven attitudes. The discrimination dimension (6 items; score range: 6-36) represents behavioral responses stemming from negative attitudes. For all dimensions, higher scores indicate worse outcomes. These 3 dimensions(as sub-scale scores) for stereotyping, prejudice, and discrimination will also be calculated and analyzed.

    Time frame: pre-test (Baseline) and post-test (Week 4)

07

Results

Posted Aug 2, 2024

Participant flow

Participant flow — Overall Study
MilestoneGet a Learning Material and a Experiential HIV TestingGet a Learning Material Only
Started3737
Completed3636
Not completed11
Withdrew: Lost to follow-up11

Outcome measures

PrimaryHIV Testing Related Knowledge and Practice

A self-development scale, known as the "HIV Testing-Related Knowledge and Practice Scale," is employed to assess individuals' knowledge and practices pertaining to HIV testing. The scale consists of twenty-eight questions, encompassing both True-False and multiple-choice formats. Participants earn one point for each correct answer, contributing to a total score that ranges from the minimum scores of 0 to the maximum scores of 28. Higher scores signify a more positive outcome, indicating enhanced HIV testing-related knowledge and practice among the participants.

Time frame:
pre-test(Baseline) and post-test (week 4)
Reported as:
Mean · score on a scale
HIV Testing Related Knowledge and Practice
score on a scaleGet a Learning Material and a Experiential HIV TestingGet a Learning Material Only
pre-test17.17 ± 1.8817.22 ± 2.14
post-test19.44 ± 2.2117.36 ± 2.69
Statistical analysis
  • Get a Learning Material and a Experiential HIV Testing vs Get a Learning Material Only · ANCOVA · p = <0.001 (The p-value is adjusted for multiple comparisons using the Bonferroni correction, with a significance threshold of 0.05.) · Adjusted mean difference (ancova): 2.07
PrimaryHIV Related Stigma

The Healthcare Provider HIV/AIDS Stigma Scale (HPASS) will be used to assess this outcome. The instrument contains 30 items, each scored on a six-point Likert scale, yielding a minimum total score of 30 and a maximum of 180. Higher scores reflect greater levels of stigma toward people living with HIV, indicating a worse outcome. Validation of the HPASS through factor analysis identified three underlying dimensions. The stereotyping dimension (11 items; score range: 11-66) reflects negative cognitions and beliefs about people living with HIV. The prejudice dimension (13 items; score range: 13-78) captures emotionally driven attitudes. The discrimination dimension (6 items; score range: 6-36) represents behavioral responses stemming from negative attitudes. For all dimensions, higher scores indicate worse outcomes. These 3 dimensions(as sub-scale scores) for stereotyping, prejudice, and discrimination will also be calculated and analyzed.

Time frame:
pre-test (Baseline) and post-test (Week 4)
Reported as:
Mean · score on a scale
HIV Related Stigma
score on a scaleGet a Learning Material and a Experiential HIV TestingGet a Learning Material Only
(pre-test)HPASS in total89.39 ± 16.1486.75 ± 22.06
(post-test)HPASS in total85.94 ± 20.1088.03 ± 20.44
(pre-test)stereotyping36.36 ± 6.8538.36 ± 8.43
(post-test)stereotyping36.31 ± 7.6638.03 ± 9.20
(pre-test)prejudice35.78 ± 8.5134.44 ± 12.11
(post-test)prejudice33.14 ± 10.7334.72 ± 10.31
(pre-test)discrimination17.25 ± 5.6113.94 ± 5.68
(post-test)discrimination16.50 ± 5.5915.28 ± 5.32
Statistical analysis
  • Get a Learning Material and a Experiential HIV Testing vs Get a Learning Material Only · ANCOVA · p = 0.15 (The p-value is adjusted for multiple comparisons using the Bonferroni correction, with a significance threshold of 0.05.) · Adjusted mean difference (ancova): 4.58
  • Get a Learning Material and a Experiential HIV Testing · t-test, 2 sided · p = 0.02 (The p-value is adjusted for multiple comparisons using the Bonferroni correction, with a significance threshold of 0.05.) · Median difference (final values): -2.64

Adverse events

Collected over 1 year. Non-serious events are listed at a 0% frequency threshold.

Adverse event summary by group
GroupDeathsSeriousOther
Get a Learning Material and a Experiential HIV Testing0/72 (0%)0/72 (0%)0/72 (0%)
Get a Learning Material Only0/72 (0%)0/72 (0%)0/72 (0%)

Baseline characteristics

Age, Continuous
Age, Continuous(years)Get a Learning Material and a Experiential HIV TestingGet a Learning Material OnlyTotal
Mean28.03 ± 4.5829.14 ± 5.7428.58 ± 5.19
Sex: Female, Male
Sex: Female, Male(Participants)Get a Learning Material and a Experiential HIV TestingGet a Learning Material OnlyTotal
Female282856
Male8816
Race (NIH/OMB)
Race (NIH/OMB)(Participants)Get a Learning Material and a Experiential HIV TestingGet a Learning Material OnlyTotal
American Indian or Alaska Native000
Asian363672
Native Hawaiian or Other Pacific Islander000
Black or African American000
White000
More than one race000
Unknown or Not Reported000
Region of Enrollment
Region of Enrollment(participants)Get a Learning Material and a Experiential HIV TestingGet a Learning Material OnlyTotal
Taiwan363672
education level
education level(Participants)Get a Learning Material and a Experiential HIV TestingGet a Learning Material OnlyTotal
bachelor's degree333366
master's degree336
Marital status
Marital status(Participants)Get a Learning Material and a Experiential HIV TestingGet a Learning Material OnlyTotal
married4610
single323062
Nursing practice years
Nursing practice years(years)Get a Learning Material and a Experiential HIV TestingGet a Learning Material OnlyTotal
Mean5.06 ± 4.496.18 ± 5.285.62 ± 4.90
Nursing practice years in the ED
Nursing practice years in the ED(years)Get a Learning Material and a Experiential HIV TestingGet a Learning Material OnlyTotal
Mean3.6 ± 3.644.77 ± 4.324.18 ± 4.01

4 further baseline measures are reported on the registry.

08

Study locations

1 site
  • School of Nursing of National Taiwan University
    Taipei, 100, Taiwan
09

References and documents

Publications

  • He CR, Chang JC, Liu CY, Yang BJ, Hung YH, Chiou PY. Enhancing HIV knowledge and reducing stigma among emergency nurses through experiential self-testing: A mixed-methods study. Nurse Educ Pract. 2026 Feb;91:104694. doi: 10.1016/j.nepr.2025.104694. Epub 2025 Dec 18. PubMed 41455361 ↗

Study documents

  • Protocol and statistical analysis plan · Apr 20, 2023

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: No

10

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 1, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
11

Registry details

Key details

Study ID
NCT05615935
Lead sponsor
National Taiwan University
Responsible party
Piao-Yi Chiou (Associate Professor, National Taiwan University) — Principal investigator
First posted
Nov 14, 2022
Start date
Nov 9, 2022
Primary completion
Feb 1, 2023
Completion
Feb 23, 2023
Results posted
Aug 2, 2024
Last update
Oct 1, 2025

Study contacts

CHENG-RU HE, Bachelor
principal investigator · National Taiwan University Hospital

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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