An interventional study of Isocaloric ketogenic diet in Ketogenic Dieting, Altitude Hypoxia and Physical Activity, sponsored by Clinique Romande de Readaptation. Completed at 1 site in Switzerland. Open to participants aged 20 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-11-03.
Sponsored by Clinique Romande de Readaptation · Not applicable, Interventional, and Basic science
A ketogenic diet (KD) reduces daily carbohydrates (CHOs) ingestion by replacing most calories with fat. KD is of increasing interest among athletes because it may increase their maximal oxygen uptake (VO2max), the principal performance limitation at high altitudes. The investigators examined the tolerance of a 4-week isocaloric KD (ICKD) under simulated hypoxia and the possibility of evaluating ICKD performance benefits with a maximal graded exercise bike test under hypoxia and collected data on the effect of the diet on performance markers and arterial blood gases.
In a randomised single-blind cross-over model, 6 recreational mountaineers (age 24 to 44 years) will complete a 4-week ICKD followed or preceded by a 4-week habitual mixed western diet (HD). Performance parameters (VO2max, lactate threshold [LT], peak power [Ppeak]) and arterial blood gases (PaO2, PaCO2, pH, HCO3-) will be measured at baseline under two conditions (normoxia and hypoxia) as well as after a 4-week HD and 4-week ICKD under the hypoxic condition.
216 studies on the registry are indexed under Altitude Sickness; 46 are open to participants now.
This study's enrollment of 8 is below the median of 34 across 178 interventional studies indexed under Altitude Sickness.
Browse Altitude Sickness studies →Clinique Romande de Readaptation is the lead sponsor of 9 studies on the registry; none are open to participants now.
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Exclusion Criteria:
no limitations on food consumption.
Dietary Supplement: Isocaloric ketogenic diet
We defined ICKD as a daily CHOs ingestion \< 30 to 50 g.d-1, without any limitation in fat consumption.
Dietary Supplement: Isocaloric ketogenic diet
The ICKD definition was based on the works of Sansone (2018) and Trimboli (2020). We defined ICKD as a daily CHOs ingestion \< 30 to 50 g.d-1, without any limitation in fat consumption. Participants self-selected their own diet based on a list of advised and forbidden foods developed to fit the definition of ICKD. There were no instructions to limit calories.
Performance test under hypoxic conditions
VO2max cycling test on ergometer
Time frame: after 4 weeks of diet
Plan to share: No
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This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.
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Clinique Romande de Readaptation