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RecruitingNCT05581680AQ2MFUpdated May 28, 2025

Multimodal Quantified Analysis of Facial Movements: Comparison Between Pathological and Control Subjects

An interventional study of dental impressions and Simultaneous MoCap and EMG acquisition in Electromyography, Eye-tracking and Facial Palsy, sponsored by Centre Hospitalier Universitaire, Amiens. Recruiting at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-05-28.

Sponsored by Centre Hospitalier Universitaire, Amiens · Not applicable, Interventional, and Other

From the registry’s dates

  • Started Oct 2022; still recruiting 4 years 1 month later.
Phase
Not applicable
Study type
Interventional
Enrollment
720
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

The facial palsy is a frequent disease with a lot of etiologies. It has variable severities with sometimes heavy functional repercussions and different recovery potentials. The proposed treatments are based on surgery, physiotherapy and botulinum toxin injections. However, when recovery is incomplete, acceptance is more difficult, with an impacted quality of life. Thanks to Motion Capture and Electromyography, a quantification of the facial mimicry is now possible with a great precision. In addition with the quantification of the facial mimicry, eye-tracking, wich is widely used in the marketing field, but it also finds medical applications including head and neck lesions and facial palsy in particular, will be used to evaluate the visio of the patients on their pathology in function of the movement quantification measured with MoCap and Electromyography. The aim of this research is to measure in a combined way the action potentials by sEMG and the amplitudes of displacement of the markers in motion capture, for movements determined in a population of patients presenting a facial pathology, in order to compare them with reference values obtained in healthy subjects. In a second step, the aim will be to study if there is a link between the way the patient looks at his pathology and the results of his management (treatment, rehabilitation) which will be quantitatively evaluated thanks to MoCap and sEMG.

02

Conditions studied

  • Electromyography
  • Eye-tracking
  • Facial Palsy

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Keywords

  • facial mimics
  • motion capture
  • electromyography
  • eye-tracking
  • Facial Palsy
03

In context

Facial Paralysis

81 studies on the registry are indexed under Facial Paralysis; 28 are open to participants now.

This study's planned enrollment of 720 is above the median of 50 across 59 interventional studies indexed under Facial Paralysis.

Browse Facial Paralysis studies →

Lead sponsor

Centre Hospitalier Universitaire, Amiens is the lead sponsor of 586 studies on the registry; 185 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Subjects with no known facial pathology (healthy volunteers) OR
  • Patients with peripheral facial palsy, irrespective of grade, whether or not previously treated
  • Subject with written
  • Subject over 18 years of age
  • Subject affiliated to a social security scheme

Exclusion criteria

Exclusion Criteria:

  • Subjects with severe skin disorders that do not allow the application of electrodes or photo reflective markers
  • Subjects with speech disorders making it impossible to pronounce the sounds [o] and [pu]
  • Subject unable to provide written
  • Subjects under guardianship, curators or safeguard of justice
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

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05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
720 participants (estimated)

Study arms

  • Experimental
    patients with facial palsy

    Other: dental impressions · Other: Simultaneous MoCap and EMG acquisition · Other: Eye-tracking acquisition for pathological subjects · Other: Follow-up visit for pathological subjects

  • Active comparator
    healthy volunteers

    Other: dental impressions · Other: Simultaneous MoCap and EMG acquisition

Interventions

  • Otherdental impressions

    dental impressions

  • OtherSimultaneous MoCap and EMG acquisition

    Simultaneous MoCap and EMG acquisition

  • OtherEye-tracking acquisition for pathological subjects

    Eye-tracking acquisition for pathological subjects

  • OtherFollow-up visit for pathological subjects

    Follow-up visit for pathological subjects

06

What researchers measure

Primary outcomes

  1. determination of baseline values of facial mimicry (in millimetres) in healthy volunteers

    determination of baseline values of facial mimicry (in millimetres) in healthy volunteers

    Time frame: one month

  2. determination of baseline values of eye-tracking (in millimetres) in healthy volunteers

    determination of baseline values of eye-tracking (in millimetres) in healthy volunteers

    Time frame: one month

  3. determination of the maximum range of motion of facial mimicry (in millimetres) in patients

    determination of the maximum range of motion facial mimicry (in millimetres) in patients

    Time frame: one year

  4. determination of the maximum range of motion of eye-tracking (in millimetres) in patients

    determination of the maximum range of motion of eye-tracking (in millimetres) in patients

    Time frame: one year

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 28, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05581680
Responsible party
Sponsor
First posted
Oct 14, 2022
Start date
Oct 12, 2022
Primary completion
Oct 2027 (estimated)
Completion
Oct 2028 (estimated)
Last update
May 28, 2025

Study contacts

Stéphanie Dakpé, Pr
Contact
dakpe.stephanie@chu-amiens.fr
03 22 08 90 50

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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