An observational study in Acute Ischemic Stroke, sponsored by Ruhr University of Bochum. Status unknown at 1 site in Germany. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-10-17.
Sponsored by Ruhr University of Bochum · Observational
Single-center prospective observational study investigating the association of brainstem raphe hypoechogenicity detected by transcranial sonography and post-stroke depression three months after an acute ischemic stroke.
Post-stroke depression (PSD) is an important complication after a stroke. Despite significant limitations between studies of PSD risk factors, stroke severity or post-stroke disability, prior depressive episodes, and female sex are arguably the most well-known risk factors for developing PSD, although the predictive value of these factors is limited.
A hypoechogenic brainstem raphe (BR) detected by transcranial sonography (TCS) is associated with depressive symptoms in distinct diseases but is also common with approximately 25% of the non-depressed population in Europe. The primary aim of this study is to investigate the association between BR hypoechogenicity and PSD occurrence in a prospective observational study design.
7,286 studies on the registry are indexed under Stroke; 2,013 are open to participants now.
This study's planned enrollment of 105 is below the median of 160 across 1,692 observational studies indexed under Stroke.
Browse Stroke studies →Ruhr University of Bochum is the lead sponsor of 124 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients who present with an acute ischemic stroke to the emergency department with the onset of symptoms within the past 14 days.
Exclusion Criteria:
Acute ischemic stroke patients with brainstem raphe hypoechogenicity.
Diagnostic Test: Transcranial sonography.
Acute ischemic stroke patients without brainstem raphe hypoechogenicity.
Diagnostic Test: Transcranial sonography.
Transcranial sonography examination to determine the brainstem raphe echogenicity.
Post-stroke depression
PSD diagnosis was defined according to the fifth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V criteria) or by any new medication for anti-depressive indication during follow-up
Time frame: 3 months
Severity of depressive symptoms
Measured by the Hamilton Depression Rating Scale (HRSD, minimum score: 0, maximum score: 52), with higher scores indicating greater severity of depressive symptoms.
Time frame: 3 months
Plan to share: Undecided
No publications or documents are linked to this record.
This study is status unknown, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.
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Ruhr University of Bochum