An interventional study of Multicomponent Training in Aging Disorder, Obesity and Inflammation, sponsored by University of Sao Paulo. Status unknown at 1 site in Brazil. Open to female participants aged 60 Years to 75 Years. Per ClinicalTrials.gov, last updated 2022-09-23.
Sponsored by University of Sao Paulo · Not applicable, Interventional, and Health services research
Population aging worldwide has increased substantially in recent years. In order to prevent disabling diseases and improve the quality of life, it is necessary to understand the conditions related to the health of this specific population. One of the known alterations that occur in the body is the increased low-grade systemic inflammatory process, anabolic resistance, and muscle catabolism. These conditions can negatively interfere with muscle quality and functionality. However, the maintenance of the metabolic and physical functionality of muscle tissue can be preserved by performing physical exercises throughout life because of its anti-inflammatory mechanisms. In the present study, a multicomponent training program that combines aerobic, strength, balance, and flexibility capacities was used. The hypothesis is that performing this type of physical exercise will mitigate meta-inflammation and its negative effects, in addition to stimulating anabolic signals and reducing insulin resistance present in anabolic resistance, leading to improved quality and muscle functionality in elderly women with obesity.
Population aging worldwide has increased substantially in recent years. Therefore, it is necessary to know and understand the conditions related to the health of this specific population in order to prevent disabling diseases and improve the quality of life. One of the major concerns associated with the senescence process is the various physiological changes that can occur in the body. Body composition changes, bone loss, muscle catabolism, an increased low-grade systemic inflammatory process, and anabolic resistance all contribute to the development and/or worsening of several aging-related diseases. In particular, chronic low-grade inflammation, also known as meta-inflammation, can negatively interfere with muscle quality and functionality by reducing the muscle's ability to use energy substrates, amino acids, and perform protein synthesis. However, the maintenance of the metabolic and physical functionality of muscle tissue can be preserved by performing physical exercise throughout life because physical exercise can stimulate anti-inflammatory mechanisms. In the present study, a multicomponent training program will be used, which consists of training that combines aerobic, strength, balance, and flexibility capacities, and is capable of reducing inflammatory parameters and increasing physical and muscular capacities, resulting in a better quality of life and being thus attractive to this specific population. In view of this approach, the hypothesis is that performing this type of physical exercise is capable of mitigating meta-inflammation and its negative effects, in addition to stimulating anabolic signals and reducing insulin resistance present in anabolic resistance, leading to improved quality and muscle functionality in elderly women with obesity.
3,439 studies on the registry are indexed under Inflammation; 629 are open to participants now.
This study's planned enrollment of 38 is below the median of 50 across 2,437 interventional studies indexed under Inflammation.
Browse Inflammation studies →University of Sao Paulo is the lead sponsor of 1,005 studies on the registry; 90 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Patients will recieve no intervention for the period of 12 weeks
Patients will undergo a 12 week multicomponent training program
Other: Multicomponent Training
Participants will perform a multicomponent training that explores strength, aerobic and balance capacities with load progression every 15 days. The sessions will last 60 minutes each, being held three times a week with a day of rest in between. The intervention will last 12 weeks
Changes in inflamatory markers
Evaluate the inflamatory markers PCR, IL-1β, IL-6, IL-10, IL-15, TNF-α, NFκβ, NLRP3, myonectin, SIRT1, sTNFR1, IL-10, IL-13, adiponectin
Time frame: 12 weeks
Changes in muscle quality
Evaluate the quantity of intramuscular fat deposits trough ultrasound pre and post intervention
Time frame: 12 weeks
Changes in muscle function
Evaluate the muscle function trough the load test pre and post intervention
Time frame: 12 weeks
Changes in metabolic parameters - fasting blood glucose
Changes in fasting blood glucose samples in pre and post intervention
Time frame: 12 weeks
Changes in metabolic parameters - insulin sensitivity
Changes in insulin sensitivity, estimated through HOMA-IR pre and post intervention
Time frame: 12 weeks
Changes in muscle remodeling peptides
Changes in PNPLA3 and PNP3 in blood samples in pre and post intervention
Time frame: 12 weeks
Body composition changes
Changes in fat-free mass and fat mass evaluated pre and post intervention by iDEXA
Time frame: 12 weeks
Changes of physical performance
Physical performance changes, evaluated through physical tests.
Time frame: 12 weeks
Changes in blood myostatin
Changes in blood myostatin levels pre and post intervention
Time frame: 12 weeks
Indirect calorimetry assessment
Changes in resting metabolic rate (RMR) evaluated pre and post intervention by indirect calorimetry
Time frame: 12 weeks
Changes in metabolic parameters - lipid profile
Changes in lipid profile (total cholesterol, HDL-c, LDL-c, triglycerides)samples in pre and post intervention
Time frame: 12 weeks
Plan to share: No
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University of Sao Paulo