An interventional study of Isometric exercise training in Heart Failure With Preserved Ejection Fraction, sponsored by St George's, University of London. Status unknown. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-10-26.
Sponsored by St George's, University of London · Not applicable, Interventional, and Prevention
Heart failure with a preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Hypertension remains one of the major modifiable risk factors in HFpEF development and progression. The role of aerobic exercise training for blood pressure (BP) reduction is well established, with positive cardiac, vascular, and neurohumoral adaptations all cited as potential mechanisms for improving arterial haemodynamics. However, recent evidence has shown that a specific type of resistance exercise alone, known as isometric exercise (IE), produces greater mean BP reductions than what has traditionally been seen with both aerobic and dynamic resistance exercise training programmes. Indeed, short duration IE training causes significant improvements in both cardiac structure and function, in addition to inducing significant reductions in resting BP in normotensive, pre-hypertensive and hypertensive individuals. This study aims to compare the acute and chronic effects of an IE training intervention on diastolic function parameters in patients who have been diagnosed with HFpEF compared to a control group.
5,697 studies on the registry are indexed under Heart Failure; 1,219 are open to participants now.
This study's planned enrollment of 48 is below the median of 72 across 3,733 interventional studies indexed under Heart Failure.
Browse Heart Failure studies →St George's, University of London is the lead sponsor of 105 studies on the registry; 11 are open to participants now.
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Other: Isometric exercise training
Participants randomised to the intervention will perform a 4-week programme of isometric exercise training.
Diastolic function
Whether an isometric exercise training (IET) programme statistically significantly improves diastolic function parameters in patients who have been diagnosed with HFpEF. These parameters will be measured quantitatively using transthoracic echocardiography and using measures of transmitral filling velocity (early \[E\] and late \[A\] left ventricular filling velocities), the E/A ratio and tissue Doppler velocities (mitral annulus velocities in diastole \[E'\]) and the E/E' ratio.
Time frame: 1-year
Blood pressure
Isometric exercise training has been shown to reduce systolic and diastolic blood pressure (mmHg). Our secondary outcome measure is to record any statistically significant changes in blood pressure following a programme of isometric exercise training compared to a control group.
Time frame: 1-year
No study locations are listed for this record.
Plan to share: Undecided
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This study is status unknown, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.
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St George's, University of London