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RecruitingNCT05509101Updated May 6, 2026

Improving Myoelectric Prosthetic and Orthotic Limb Control

An interventional study of commercially available control algorithm and experimental control algorithm in Hemiparesis, sponsored by University of Utah. Recruiting at 1 site in United States. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-06.

Sponsored by University of Utah · Not applicable, Interventional, and Other

From the registry’s dates

  • Registered 5 years 5 months after the study started (first participant enrolled Mar 2017, registered Aug 2022).
  • Started Mar 2017; still recruiting 9 years 8 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
45
Allocation
Randomized
Ages
18 Years to 70 Years
Sex
All
01

Study summary

The purpose of this study is to improve control of myoelectrically-controlled advanced orthotic devices (an exoskeleton device that use the body's muscle signals to drive movements of a robotic brace) by using advanced predictive decode algorithms, and the use of high count (> 8) surface electromyographic (sEMG) electrodes.

Read the detailed description

This study looks to improve control of myoelectrically-controlled advanced powered orthoses (orthoses that use the body's muscle signals to drive movements of a robotic exoskeleton) by using advanced predictive decode algorithms, and the use of high count (> 8) surface electromyographic (sEMG) electrodes.

02

Conditions studied

  • Hemiparesis

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03

In context

Paresis

468 studies on the registry are indexed under Paresis; 117 are open to participants now.

This study's planned enrollment of 45 is above the median of 37 across 420 interventional studies indexed under Paresis.

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Lead sponsor

University of Utah is the lead sponsor of 994 studies on the registry; 175 are open to participants now.

Of its 114 completed or terminated interventional studies of FDA-regulated products, 69 (61%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • First-ever ischemic or hemorrhagic stroke
  • Chronic Stroke (at least 6 months since onset)
  • Chronic hemiparesis
  • Functional range of motion for contralateral arm

Exclusion criteria

Exclusion Criteria:

  • Individuals who are currently Incarcerated
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Participant)
Enrollment
45 participants (estimated)

Study arms

  • Active comparator
    Clinically Available Control Algorithm (MyoPro)

    Binary control of the orthosis is based on a clinically available control algorithm. This condition serves as a control. Participants will use a commercially available device, the MyoPro.

    Other: commercially available control algorithm

  • Experimental
    High-Density EMG Control Algorithm

    Control of the orthosis is based on residual muscle activity mapped to intended movement using advanced predicted algorithms. This condition is a novel algorithm and serves as the experimental condition.

    Other: experimental control algorithm

Interventions

  • Othercommercially available control algorithm

    Control of the prosthesis/orthosis is based on clinical standard of care using commercially available control algorithms.

  • Otherexperimental control algorithm

    Control of the orthosis is based on residual muscle activity mapped to intended movement using high density electromyography and artificial intelligence control algorithms.

06

What researchers measure

Primary outcomes

  1. Box and Blocks Test (BBT)

    The Box and Blocks test is performed using the orthotic device under each condition. The individual puts on the device for a maximum of two hours. During that time wearing the device, they will use two different algorithms for controlling the device to complete the Box and Blocks Test.

    Time frame: while using the device (up to 2 hours)

07

Study locations

1 of 1 sites recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 6, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT05509101
Lead sponsor
University of Utah
Responsible party
Jacob George (Assistant Professor, University of Utah) — Principal investigator
First posted
Aug 19, 2022
Start date
Mar 1, 2017
Primary completion
Jul 31, 2027 (estimated)
Completion
Dec 31, 2027 (estimated)
Last update
May 6, 2026

Study contacts

Heidi Hansen, BS
Contact
heidi.hansen@hsc.utah.edu
801.585.2373
Jacob Wilson, BS
Contact
jacob.wilson@hsc.utah.edu
801.581.8911

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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