An interventional study of Navigation-guided surgery in Tumor, Brain, Meningioma of Brain and Glioma, sponsored by Sklifosovsky Institute of Emergency Care. Recruiting at 1 site in Russia. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by Sklifosovsky Institute of Emergency Care · Not applicable, Interventional, and Treatment
The purpose of the study is to calculate magnitude, type of intraoperative brain shift and assess possibility of it's prediction.
Brain shift is the main natural cause of major navigation imprecision. Despite numerous attempts no clinical trials have demonstrated a possibility to calculate and predict its value although some patterns were found. Some modern navigational features allow to partially resolve this problem. Manual shift correction allows to displace brain structures but can only be used if brain shift is linear. Intraoperative computed tomography (CT) and magnetic resonance imaging (MRI) allow to update navigational data but violate surgical workflow and cannot display brain tissue in real time. Intraoperative sonography has lower spatial resolution, limited field of view and steep learning curve.
The purpose of the study is to calculate magnitude, type of intraoperative brain shift and assess possibility of its prediction.
For each patient the investigator intraoperatively will assess location of brain surface, and lesion margins during surgery. Postoperatively these data will be compared to tumor characteristics, patient's state and intraoperative features.
2,440 studies on the registry are indexed under Brain Neoplasms; 540 are open to participants now.
This study's planned enrollment of 100 is above the median of 40 across 1,831 interventional studies indexed under Brain Neoplasms.
Browse Brain Neoplasms studies →Sklifosovsky Institute of Emergency Care is the lead sponsor of 13 studies on the registry; 7 are open to participants now.
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The criteria were revised on the registry on Oct 15, 2026. See what changed
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
Metastases
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Removing different brain lesions using neuronavigation
Device: Navigation-guided surgery
Surgeon removes brain lesions and assesses brain shift with neuronavigation
Brain shift (in millimeters)
Maximal difference between disposition of different brain structures in preoperative scans and it's real intraoperative location
Time frame: Intraoperatively
Extent of resection (in percents)
Extent of Extent of resection = (preoperative tumor volume - postoperative tumor volume) / preoperative tumor volume x 100resection (in percents)
Time frame: Within 48 hours after surgery
Karnofsky Performance status in percents
Assesses patients' possibilities to self-service
Time frame: within 10 days after surgery
Cerebral complications
Which cerebral complications arose after surgery
Time frame: From admission to intensive care unit after surgery till hospital discharge, up to 365 days
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Sklifosovsky Institute of Emergency Care