Postoperative Delirium in the ICU Setting of an Eastern European Centre

Browse trials for

• Delirium 1,057
• Emergence Delirium 763

Keywords

• postoperative delirium
• abdominal surgery
• malondialdehyde
• S100B protein
• Tau protein
• pNF-H
• Bispectral Index
• anesthesia depth
• general anesthesia

Delirium

1,057 studies on the registry are indexed under Delirium; 238 are open to participants now.

This study's planned enrollment of 100 is below the median of 200 across 418 observational studies indexed under Delirium.

Lead sponsor

Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor is the lead sponsor of 5 studies on the registry; 2 are open to participants now.

Study population

Groups and cohorts

• BIS monitoring

  Patients in this group will be subjected to Bispectral index-guided general anesthesia.

  Device: BIS monitoring

• PRST score monitoring

  Patients in this group will be subjected PRST score-guided general anesthesia.

Interventions

• DeviceBIS monitoring

  The depth of anesthesia will be monitored using Bispectral Index values.

Primary outcomes

1. Prediction model for postoperative delirium (POD) in major abdominal surgery

   Developing an accesible algorithm to anticipate the occurence of postoperative delirium, based on functional baseline and proteomics, in adult patients subjected to major abdominal surgical interventions. This includes investigating a correlation between a set of risk factors, a panel of biomarkers and the occurrence of postoperative delirium in the enrolled patients, respectively.

   Time frame: 3-4 years

Secondary outcomes

1. Anesthesia depth monitoring and the incidence of postoperative delirium

   Assessing the influence of BIS monitoring during general anesthesia on the prevalence of postoperative delirium

   Time frame: 0-4 days postoperatively

2. Postoperative delirium incidence in surgical patients in the Intensive Care Unit (ICU) setting

   Time frame: during ICU hospitalization

3. Postoperative delirium incidence in surgical patients - subgroup - communism survivors

   Time frame: during ICU hospitalization

4. Postoperative delirium incidence in surgical patients - subgroup - patients with no relatives/visitors

   Time frame: during ICU hospitalization

Other outcomes

1. The influence of POD on length of stay (LOS), unplanned ICU re-admission, cognitive decline and mortality

   Evaluating the possibility of a correlation between the occurence of POD and prolonged hospitalization, a prerequisite for ICU re-admittance or further cognitive deterioration / mortality.

   Time frame: during patient hospitalization

Publications

• Belrose JC, Noppens RR. Anesthesiology and cognitive impairment: a narrative review of current clinical literature. BMC Anesthesiol. 2019 Dec 27;19(1):241. doi: 10.1186/s12871-019-0903-7. PubMed 31881996 ↗
• Daiello LA, Racine AM, Yun Gou R, Marcantonio ER, Xie Z, Kunze LJ, Vlassakov KV, Inouye SK, Jones RN, Alsop D, Travison T, Arnold S, Cooper Z, Dickerson B, Fong T, Metzger E, Pascual-Leone A, Schmitt EM, Shafi M, Cavallari M, Dai W, Dillon ST, McElhaney J, Guttmann C, Hshieh T, Kuchel G, Libermann T, Ngo L, Press D, Saczynski J, Vasunilashorn S, O'Connor M, Kimchi E, Strauss J, Wong B, Belkin M, Ayres D, Callery M, Pomposelli F, Wright J, Schermerhorn M, Abrantes T, Albuquerque A, Bertrand S, Brown A, Callahan A, D'Aquila M, Dowal S, Fox M, Gallagher J, Anna Gersten R, Hodara A, Helfand B, Inloes J, Kettell J, Kuczmarska A, Nee J, Nemeth E, Ochsner L, Palihnich K, Parisi K, Puelle M, Rastegar S, Vella M, Xu G, Bryan M, Guess J, Enghorn D, Gross A, Gou Y, Habtemariam D, Isaza I, Kosar C, Rockett C, Tommet D, Gruen T, Ross M, Tasker K, Gee J, Kolanowski A, Pisani M, de Rooij S, Rogers S, Studenski S, Stern Y, Whittemore A, Gottlieb G, Orav J, Sperling R; SAGES Study Group*. Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence. Anesthesiology. 2019 Sep;131(3):477-491. doi: 10.1097/ALN.0000000000002729. PubMed 31166241 ↗
• Lee SH, Lim SW. Risk factors for postoperative delirium after colorectal surgery: a systematic review and meta-analysis. Int J Colorectal Dis. 2020 Mar;35(3):433-444. doi: 10.1007/s00384-019-03498-6. Epub 2020 Jan 2. PubMed 31897646 ↗
• Park SA, Tomimaru Y, Shibata A, Miyagawa S, Noguchi K, Dono K. Incidence and Risk Factors for Postoperative Delirium in Patients After Hepatectomy. World J Surg. 2017 Nov;41(11):2847-2853. doi: 10.1007/s00268-017-4079-3. PubMed 28608014 ↗
• Saxena S, Maze M. Impact on the brain of the inflammatory response to surgery. Presse Med. 2018 Apr;47(4 Pt 2):e73-e81. doi: 10.1016/j.lpm.2018.03.011. Epub 2018 Apr 12. PubMed 29656802 ↗
• Inoue R, Sumitani M, Ogata T, Chikuda H, Matsubara T, Kato S, Shimojo N, Uchida K, Yamada Y. Direct evidence of central nervous system axonal damage in patients with postoperative delirium: A preliminary study of pNF-H as a promising serum biomarker. Neurosci Lett. 2017 Jul 13;653:39-44. doi: 10.1016/j.neulet.2017.05.023. Epub 2017 May 11. PubMed 28504118 ↗
• Alam A, Hana Z, Jin Z, Suen KC, Ma D. Surgery, neuroinflammation and cognitive impairment. EBioMedicine. 2018 Nov;37:547-556. doi: 10.1016/j.ebiom.2018.10.021. Epub 2018 Oct 19. PubMed 30348620 ↗
• Evered LA, Chan MTV, Han R, Chu MHM, Cheng BP, Scott DA, Pryor KO, Sessler DI, Veselis R, Frampton C, Sumner M, Ayeni A, Myles PS, Campbell D, Leslie K, Short TG. Anaesthetic depth and delirium after major surgery: a randomised clinical trial. Br J Anaesth. 2021 Nov;127(5):704-712. doi: 10.1016/j.bja.2021.07.021. Epub 2021 Aug 28. PubMed 34465469 ↗

Individual participant data

Plan to share: No