An interventional study of Propofol and Dexmedetomidine in Respiratory Failure, Mechanical Ventilation Complication and Sedation Complication, sponsored by Anesthesia Research Group UA. Completed at 1 site in Ukraine. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-07-11.
Sponsored by Anesthesia Research Group UA · Not applicable, Interventional, and Prevention
There is a direct relationship between the sedative agent and the duration of ventilation.
Sedation and sedative agent have direct correlation to the mechanical length. As known mechanical length could increase length of the hospital stay (LOHS) and mortality rate. The right sedative agent can decrease the length go the mechanical ventilation. The goal of the research to compare 3 sedation strategies and their influence to the duration of mechanical ventilation.
1,675 studies on the registry are indexed under Respiratory Insufficiency; 300 are open to participants now.
This study's enrollment of 356 is above the median of 55 across 1,056 interventional studies indexed under Respiratory Insufficiency.
Browse Respiratory Insufficiency studies →Anesthesia Research Group UA is the lead sponsor of 5 studies on the registry; 1 is open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Refusal to participate;
Patient sedation after cardiac surgery at the intensive care unit. Continuous infusion of propofol (hypnotic agent) using a syringe pump at the dose of 1-1.5 mg / kg / h
Drug: Propofol
Patient sedation after cardiac surgery at the intensive care unit. continuous infusion of Dexmedetomidine (selective α2-adrenergic receptor (α2-AR) agonist) using a syringe pump at the dose of 0.5-1.0 mcg/ kg / h
Drug: Dexmedetomidine
Patient sedation after cardiac surgery at the intensive care unit. Continuous infusion of propofol using a syringe pump at the dose of 0.5-1.5 mg / kg / h and dexmedetomidine 0.2-0.7 mcg\\kg\\h
Drug: Propofol and dexmedetomidine
patient sedation with a propofol (sedative agent) after cardiac surgery
patient sedation with dexmedetomidine (selective α2-adrenergic receptor (α2-AR) agonist) after cardiac surgery
Drug pages: Propofol · Dexmedetomidine
Patients sedation with a drug combination: propofol and dexmedetomidine (selective α2-adrenergic receptor (α2-AR) agonist)
length of the mechanical ventilation
measure the length of the mechanical ventilation
Time frame: after cardiac surgery till extubation (up to first 24 hour after surgery)
Length of the ICU stay
thе amount of the days spent in the ICU
Time frame: at the day of discharge of ICU (assessed up to day 5)
Length of the hospital stay
thе amount of the days spent in the hospital
Time frame: at the day of discharge of hospital (assessed up to day 5)
This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Propofol · Dexmedetomidine
Anesthesia Research Group UA