An interventional study of programed intermittent epidural bolus interval 90 (EI90) in Labour Pain, sponsored by Menoufia University. Completed at 2 sites in Egypt. Open to female participants aged Up to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-08-30.
Sponsored by Menoufia University · Not applicable, Interventional, and Treatment
Multiple studies showed the numerous advantages of implementing programmed epidural bolus (PIEB) technique, where a fixed volume of local anesthetic is automatically administrated at a set time interval compared to the continuous epidural infusion technique (CEI). The advantages were improved maternal satisfaction, decreased local anesthetic consumption, and decreased second stage of labor.The theory behind PIEB is that to attain a more uniform spread of local anesthetic in the epidural space a higher volume of injectate and a higher pressure is needed.Different approaches using different timings and volumes for PIEB have been proposed to achieve the optimal regimen. Many studies showed evidence that 10 mL boluses of bupivacaine 0.0625% with fentanyl 2 μg/mL delivered every 40 min, named effective programed intermittent epidural bolus interval 90 (EI90), produced effective analgesia without breakthrough pain in 90% of nulliparous women during the first stage of labor.
396 studies on the registry are indexed under Labor Pain; 66 are open to participants now.
This study's enrollment of 30 is below the median of 100 across 326 interventional studies indexed under Labor Pain.
Browse Labor Pain studies →Menoufia University is the lead sponsor of 192 studies on the registry; 53 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients of ASA physical status 2-3 with a singleton pregnancy; gestational age \> 37 weeks; regular uterine contractions occurring at least every 5 min; cervical dilation 2-5 cm; and pain \> 5
Device: programed intermittent epidural bolus interval 90 (EI90)
Patients of ASA physical status 2-3 with a singleton pregnancy; gestational age \> 37 weeks; regular uterine contractions occurring at least every 5 min; cervical dilation 2-5 cm; and pain \> 5
Device: programed intermittent epidural bolus interval 90 (EI90)
programed intermittent epidural bolus interval 90 (EI90) of 10 ml, 0.0625% bupivacaine plus 2 μg/mL fentanyl
adequate labour analgesia
Time of first call for bolus dose of epidural After loading dose
Time frame: six hours
Upper sensory block
Secsensory block level to ice
Time frame: 24hours
Visual Analogue Scale to pain
As zero is no pain and 10 is the maximum pain that can be felt
Time frame: 24 hours
Motor block
Motor block measured by bromage scale
Time frame: 24 hours
Total anaesthetic volume
Total volume of local anesthetic used
Time frame: 24 hours
Side effects
Presence of side effects as neusea, vomiting,peruritis
Time frame: 24 hours
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2024. You cannot join it, but the record below documents what was studied.
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Menoufia University