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CompletedNCT05435118EMONOUpdated Apr 23, 2024

Use of the Equimolar Mixture of Oxide Nitrous and Oxygen (EMONO) Associated With Audiovisuals in Children

An interventional study of EMONO + audiovisuals tool in Pain, Acute, Child, Only and Nurse's Role, sponsored by Azienda Socio Sanitaria Territoriale di Lodi. Completed at 1 site in Italy. Open to participants aged 2 Years to 5 Years. Per ClinicalTrials.gov, last updated 2024-04-23.

Sponsored by Azienda Socio Sanitaria Territoriale di Lodi · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
120
Allocation
Randomized
Ages
2 Years to 5 Years
Sex
All
01

Study summary

Children experience numerous painful experiences from nursing procedures: peripheral venous access placement is the main cause of procedural pain.

As much as pharmacological and nonpharmacological tools are known, their application during venipuncture is not systematic by children's hospitals.

Among pharmacological tools, the Equimolar Mixture of Nitrogen Protoxide and Oxygen (EMONO) provides adequate protection from procedural pain through inhalation of the gas mixture at least 3 minutes before the procedure.

Literature reports that the combination of nonpharmacological distractive tools and pharmacological interventions increases their analgesic effect.

The aim of the study is to measure children's cooperation during procedure (primary outcome), pain perception and side effects when EMONO is combined with audiovisuals compared with EMONO alone in peripheral venous access placement.

02

Conditions studied

  • Pain, Acute
  • Child, Only
  • Nurse's Role
  • Nitrous Oxide

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03

Who can participate

Ages eligible
2 Years to 5 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age between 2 years and 5 years and 364 days
  • Prescription for peripheral venous access placement
  • Parental consent for participation in the study
  • Presence of at least one parent in possession of a smartphone/tablet with the ability to connect to the Internet through Wi-Fi available to users
  • Absence of contraindications to the administration of EMONO reported in health records
  • Absence of facial pathology
  • Presence on duty of at least one experimental nurse trained in the use of EMONO

Exclusion criteria

Exclusion Criteria:

  • Age less than 2 years and more than 5 years and 364 days
  • No parental consent to participate in the study
  • Parents not in possession of a smartphone/tablet with the ability to connect to the internet through Wi-Fi available to users
  • Presence of contraindications to EMONO administration
  • Presence of facial pathology
  • Oxygen therapy
  • Presence of tracheostomy
  • Absence on duty of at least one experimental nurse trained in the use of EMONO
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
120 participants (actual)

Study arms

  • No intervention
    EMONO (usual care administered to all the children undergoing painful procedures)

    Use of the Equimolar Mixture of Oxide Nitrous and Oxygen (EMONO) with facial mask. In the hospital EMONO is administered to all the children for procedure pain control.

  • Experimental
    EMONO + audiovisuals tool

    Use of the Equimolar Mixture of Oxide Nitrous and Oxygen (EMONO) with facial mask and vision of audiovisual toll with smartphone or tablet. The intervention is represented by the audiovisual tool.

    Other: EMONO + audiovisuals tool

Interventions

  • OtherEMONO + audiovisuals tool

    EMONO + use of audiovisuals tool on smartphone or tablet

05

What researchers measure

Primary outcomes

  1. collaboration

    children cooperation during procedure assessed with Groningen Distress Rating Scale (Humphrey et al., 1992; Herd et al., 2006; Doumit et al., 2016)

    Time frame: 30 minutes

Secondary outcomes

  1. pain perception in 2 years-old children

    pain perceprion during procedure assessed with FLACC scale (Merkel et al., 1997)

    Time frame: 30 minutes

  2. pain perception in 3 to 5 years-old children

    pain perceprion during procedure assessed with Wong-Baker scale (Wong and Baker, 1988)

    Time frame: 30 minutes

  3. side effect 1

    vomiting during procedure Due to not available scales, numerical values from 0 (absence of sign) to 3 (presence of sign requiring medical intervention ) will be assigned to these signs

    Time frame: 30 minutes

  4. side effect 2

    gag reflex during procedure Due to not available scales, numerical values from 0 (absence of sign) to 3 (presence of sign requiring medical intervention ) will be assigned to these signs

    Time frame: 30 minutes

06

Study locations

1 site
  • Stefano Maiandi
    Lodi, Lombardia 26900, Italy
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT05435118
Lead sponsor
Azienda Socio Sanitaria Territoriale di Lodi
Responsible party
Stefano Maiandi (MSc PhDs - Health Professionals Directorate, Azienda Socio Sanitaria Territoriale di Lodi) — Principal investigator
First posted
Jun 28, 2022
Start date
Aug 17, 2023
Primary completion
Jan 31, 2024
Completion
Apr 22, 2024
Last update
Apr 23, 2024

Study contacts

Stefano Maiandi, PhDs
principal investigator · Azienda Socio Sanitaria Territoriale di Lodi

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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