An interventional study of Electrical stimulation in Cubital Tunnel Syndrome and Electrical Stimulation, sponsored by University of Alberta. Recruiting at 1 site in Canada. Open to participants aged 18 Years to 79 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-09.
Sponsored by University of Alberta · Not applicable, Interventional, and Treatment
Cubital tunnel syndrome is the second most common compression neuropathy. In severe cases, functional recovery, even with surgery, is often poor. Therefore, alternative adjunct treatments capable of increasing the speed of nerve regeneration are much needed.
The effect of brief conditioning electrical stimulation on nerve regeneration has been showed to be efficacy in animal studies. In this double-blind, randomized, controlled study, the investigators will compare the physiological and functional improvements post surgery compared with the controls who received surgery alone. Because electrical stimulation is reasonably well-tolerated and the treatment only takes an hour, it is a potentially feasible clinical tool for patients with severe nerve injury.
35 studies on the registry are indexed under Cubital Tunnel Syndrome; 6 are open to participants now.
This study's planned enrollment of 30 is below the median of 65 across 25 interventional studies indexed under Cubital Tunnel Syndrome.
Browse Cubital Tunnel Syndrome studies →University of Alberta is the lead sponsor of 823 studies on the registry; 169 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 3 (60%) have results posted.
Counted across the registry records on this site, refreshed daily.
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Exclusion Criteria:
1) Patients were excluded if they had concurrent nerve injury, prior surgery for CuTS or coexisting neurologic conditions
Control patients will receive cubital tunnel surgery and sham stimulation.
Procedure: Electrical stimulation
Patients in the stimulation group will receive surgery as well as 1 hour of 20 Hz electrical stimulation 7 days prior to surgery
Procedure: Electrical stimulation
Patients with cubital tunnel syndrome will receive either surgery and sham stimulation, or conditioning electrical stimulation 7 days prior to surgery
Motor unit number estimation
A quantitative physiological measure of the number of motor nerve fibres in the target muscle
Time frame: 3 years
Key pinch strength
A functional measure of the ulnar intrinsic hand muscles using a dynamometer
Time frame: 3 years
Disability of the Arm, Shoulder and Hand (DASH) Questionnaire
A questionnaire to quantify the severity of motor and sensory symptoms
Time frame: 3 years
Plan to share: No
No publications or documents are linked to this record.
Started Apr 2022 (actual). Primary completion is estimated for Mar 2028, 71 months after the start.
Of 15 interventional studies with no phase under Cubital Tunnel Syndrome, half reached primary completion within 14 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 48. This study's planned 71 months is above that.
How these figures are worked out, and which studies are left out of them.
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