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CompletedNCT05384795ATELHOUpdated Apr 5, 2023

Perioperative Atelectasis in Orthopaedic Surgery: a Prospective Study

An observational study in Atelectasis, sponsored by Eric Albrecht. Completed at 1 site in Switzerland. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-04-05.

Sponsored by Eric Albrecht · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
141
Ages
18 Years and older
Sex
All
01

Study summary

This study aims at comparing a perioperative pulmonary atelectasis score, measured by pulmonary ultrasound, in patients operated undergoing orthopedic surgery under general anesthesia, spinal anesthesia or peripheral nerve block. The association between the atelectasis score and previously identified risk factors will be studied.

Read the detailed description

Atelectasis is one of the most common pulmonary complications in the perioperative period, occurring in 85% to 90% of patients under general anesthesia. It can be responsible for hypoxemia and be associated with postoperative pulmonary complications such as pneumonia. The consequences are a prolongation of the hospital stay and an increase in mortality.

The appearance of perioperative atelectasis is mainly secondary to the induction of general anesthesia with an incidence up to 90%. The different causes are, for example, the administration of muscle relaxants, mechanical ventilation and the position of the patient.

In orthopedic surgery, many procedures are performed under spinal anesthesia or under peripheral nerve block. At present, there are no studies measuring the incidence of atelectasis in patients operated under these two techniques of locoregional anesthesia, with the exception of parturients undergoing cesarean section.

This study aims at comparing a perioperative pulmonary atelectasis score, measured by pulmonary ultrasound, in patients operated undergoing orthopedic surgery under general anesthesia, spinal anesthesia or peripheral nerve block. The association between the atelectasis score and previously identified risk factors will be studied.

02

Conditions studied

  • Atelectasis

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03

In context

Pulmonary Atelectasis

377 studies on the registry are indexed under Pulmonary Atelectasis; 93 are open to participants now.

This study's enrollment of 141 is above the median of 76 across 100 observational studies indexed under Pulmonary Atelectasis.

Browse Pulmonary Atelectasis studies →

Lead sponsor

Eric Albrecht is the lead sponsor of 7 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Participants will be patients scheduled for elective surgery at the Orthopedic Hospital from CHUV.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients over the age of 18;
  • Patients scheduled for an elective operation at the Orthopedic Hospital of CHUV;
  • Signature of the study consent

Exclusion criteria

Exclusion Criteria:

  • Thoracic deformities preventing the performance of pulmonary ultrasound (dressings, drains, fractures, etc.);
  • Refusal to participate;
  • Patient does not speak French.
  • Inability to discern
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
141 participants (actual)
Patient registry
No

Groups and cohorts

  • General anesthesia

    Other: Lung ultrasound

  • Spinal anesthesia

    Other: Lung ultrasound

  • Peripheral nerve block

    Other: Lung ultrasound

Interventions

  • OtherLung ultrasound

    Lung atelectasis score

06

What researchers measure

Primary outcomes

  1. Lung atelectasis score

    Atelectasis score based on validated ultrasound quantification (comparing different anesthesia techniques)

    Time frame: immediately after the surgery

Secondary outcomes

  1. Lung atelectasis score

    Atelectasis score

    Time frame: Four timepoints: at baseline, immediatly before surgery (after anesthesia induction), immediately after the surgery, and at the recovery room

07

Study locations

1 site
  • Centre Hospitalier Universitaire Vaudois
    Lausanne, Vaud 1005, Switzerland
08

References and documents

Individual participant data

Plan to share: Undecided — Fully anonymised IPD will be shared upon reasonable request.

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from May 2022 to primary completion in Dec 2022, 7 months.

Of 58 non-industry observational studies under Pulmonary Atelectasis, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 19. This study's 7 months is below that.

Counting every sponsor, half of 58 studies reached it within 11 months; a quarter within 6 and three quarters within 19.

How these figures are worked out, and which studies are left out of them.

Registered
May 13, 2022
First posted
May 20, 2022
StartActual
May 16, 2022
Primary completionActual
Dec 31, 2022
CompletionActual
Dec 31, 2022
Last update
Apr 5, 2023
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 5, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05384795
Lead sponsor
Eric Albrecht
Responsible party
Eric Albrecht (Prof. Dr. med, Centre Hospitalier Universitaire Vaudois) — Sponsor-investigator
First posted
May 20, 2022
Start date
May 16, 2022
Primary completion
Dec 31, 2022
Completion
Dec 31, 2022
Last update
Apr 5, 2023

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.

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Discussion

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