An interventional study of Vilanterol and Fluticasone Furoate and Indacaterol and Mometasone Furoate in Exercise Performance, sponsored by Morten Hostrup, PhD. Recruiting at 1 site in Denmark. Open to participants aged 18 Years to 39 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-04-09.
Sponsored by Morten Hostrup, PhD · Not applicable, Interventional, and Basic science
The purpose of the project is to investigate exercise performance in humans following prolonged inhalation of beta2-agonists vilanterol + fluticasone furoate or indacaterol + mometasone furoate
Morten Hostrup, PhD is the lead sponsor of 17 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
From a breathing test (spirometry): how much air you can blow out in the first second. Often given as a percentage of what is expected for your age, height and sex.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
ECG (electrocardiogram)
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
FEV1
From a breathing test (spirometry): how much air you can blow out in the first second. Often given as a percentage of what is expected for your age, height and sex.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants inhale vilanterol + fluticasone furoat
Drug: Vilanterol and Fluticasone Furoate
Participants inhale indacaterol + mometasone furoate
Drug: Indacaterol and Mometasone Furoate
Participants inhale placebo
Drug: Placebo
Drug pages: Vilanterol · Fluticasone furoate
Participants inhale 25 µg vilanterol + fluticasone furoate daily
Drug pages: Indacaterol · Mometasone Furoate
Participants inhale 125 µg indacaterol + mometasone furoate daily
Participants inhale placebo daily
Exercise capacity during a time trial
Mean power output measured in Watts during a time trial on a bike ergometer
Time frame: Through study completion, an average of 8 weeks
Lung function
Forced expiratory volume in 1 second (FEV1) measured by spirometry before and after time trial with and without beta2-agonist induced bronchodilation
Time frame: Through study completion, an average of 8 weeks
Airway inflammation
Measured by fractional nitric oxide in expired air
Time frame: Through study completion, an average of 8 weeks
Mannitol induced bronchial hyper reactivity
Assessed by decreases in FEV1 as dose response to cumulative doses of mannitol
Time frame: Through study completion, an average of 8 weeks
Exercise induced bronchial hyper reactivity
Assessed by decreases in FEV1 after maximal exercise
Time frame: Through study completion, an average of 8 weeks
Quadriceps muscle strength
Assessed by maximal isometric contraction torque
Time frame: Through study completion, an average of 8 weeks
Lean body mass
Measured with DXA-scanning
Time frame: Through study completion, an average of 8 weeks
Fat mass
Measured with DXA-scanning
Time frame: Through study completion, an average of 8 weeks
Plan to share: Yes — Deidentified data set will be shared upon reasonable request.
Supporting information: Study protocol, Statistical analysis plan, Analytic code
Time frame: Deidentified data set will be shared upon reasonable request.
No publications or documents are linked to this record.
Started Oct 2023 (actual). Primary completion is estimated for Jul 2026, 33 months after the start.
How these figures are worked out, and which studies are left out of them.
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Studies of the drugs tested here: Vilanterol · Fluticasone furoate · Indacaterol · Mometasone Furoate
Morten Hostrup, PhD