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WithdrawnNCT05341934CEAlcoolUpdated Apr 22, 2022

Evaluative Conditioning: A Brief Cognitive Intervention Aimed to Modify Addiction Behaviour of Alcohol-dependent Patients

An interventional study of Evaluative Conditionning Task in Cognitive Intervention to Modify Addiction Behaviour of Alcohol-dependent Patients, sponsored by Centre Hospitalier Henri Laborit. Withdrawn at 1 site in France. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-04-22.

Sponsored by Centre Hospitalier Henri Laborit · Not applicable, Interventional, and Treatment

Why this study was withdrawn
No Inclusion/ Study never begin

From the registry’s dates

  • Registered 2 years 6 months after the study started (first participant enrolled Jan 2018, registered Jul 2020).
Phase
Not applicable
Study type
Interventional
Enrollment
0
Allocation
Randomized
Ages
18 Years to 70 Years
Sex
All
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Study summary

Evaluative Conditioning: A Brief Cognitive Intervention Aimed to Modify Addiction Behaviour of Alcohol-dependent Patients

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Conditions studied

  • Cognitive Intervention to Modify Addiction Behaviour of Alcohol-dependent Patients

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Keywords

  • evaluative conditionning, addiction, alcohol, patients
03

In context

Behavior, Addictive

540 studies on the registry are indexed under Behavior, Addictive; 134 are open to participants now.

Browse Behavior, Addictive studies →

Lead sponsor

Centre Hospitalier Henri Laborit is the lead sponsor of 27 studies on the registry; 17 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Participants in this study will be patients:
  • With an alcohol use disorder according to DSM 5
  • Follow-up at the Laborit Hospital Center
  • Aged between 18 and 70 years with informed consent after receiving written information
  • Engaged in a process to reduce alcohol consumption
  • With a score of MOCA> 20
  • Whose mother tongue is French
  • Patients benefiting from social security or benefiting from it through a third party in accordance with the french law on research involving the human person.

Exclusion criteria

Exclusion Criteria:

    • Patient with less than 6 Heavy Drinking Days in the month
  • Patient with Schizophrenia
  • Patient with bipolar disorder Type 1
  • Patient with Korsakoff syndrome or degenerative neurological disorder
  • Patient with hearing impairment, uncorrected visual impairment
  • Patient under curatorship or guardianship
  • Patient with addiction to another substance other than tobacco
  • Patient already enrolled in another interventional study
  • Pregnant or nursing woman
  • Patient with difficulties of expression or comprehension in French
  • Patients in emergency situations or unable to give their consent.

Output Criteria:

  • Patient who has manifested verbally or in writing, the desire to leave the study in progress.
  • Patient who will be hospitalized during the study for a problem related to his addiction.
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
0 participants (actual)

Study arms

  • Active comparator
    Conditionning

    Other: Evaluative Conditionning Task

  • Placebo comparator
    Placebo

    Other: Evaluative Conditionning Task

Interventions

  • OtherEvaluative Conditionning Task

    A word will appear in one of the four quadrants on the computer screen. They will have to answer the word as quickly as possible by pressing the space bar. They will also be told that an image will be displayed briefly (400 ms) in the same quadrant by pressing the answer key. This procedure will be repeated for 120 trials: 30 trials with alcohol-related Conditional Stimulus (CS), 30 trials with CS related to non-alcoholic beverages and 60 trials with the CS of filling. The CS referring to alcohol will be the words Beer, Wine ...; The CS referring to soft drinks will be the words Coca-Cola, Fanta... and Filling CS referring to vegetables and fruits will be: Apple, Banana...In experimental conditions, alcohol-related CS will be followed by negative Unconditional Stimuli (US) (images from the International Affective Picture System (Lang, Bradley, \& Cuthbert, 1997)), CS referring to soft drinks linked to positive images and CS referring to fruits and vegetables will be linked to neutral US.

    Also known as: Implicit Association Task, Subliminal Attitude Misattribution Procedure

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What researchers measure

Primary outcomes

  1. The reduction of automatic or implicit associations of Alcohol with positive affect.

    It will be evaluated by calculating the difference between the scores of the IAT task before and after the Evaluative Conditioning.

    Time frame: baseline

Secondary outcomes

  1. The reduction in the total amount of alcohol consumed

    The reduction in the total amount of alcohol consumed (TAC: Total Alcohol Consumption) as well as the number of Heavy Drinking Day (HDD) over the 12-week period following treatment, with respect to the baseline time. The baseline time is the week before randomization. Consumption of alcohol (total quantity and consumption habits) during this period will be considered as a baseline. The HDD corresponds to the days of consumption of more than 60 grams of pure alcohol (men) or 40 grams (women).

    Time frame: week 2

  2. The reduction in the total amount of alcohol consumed

    The reduction in the total amount of alcohol consumed (TAC: Total Alcohol Consumption) as well as the number of Heavy Drinking Day (HDD) over the 12-week period following treatment, with respect to the baseline time. The baseline time is the week before randomization. Consumption of alcohol (total quantity and consumption habits) during this period will be considered as a baseline. The HDD corresponds to the days of consumption of more than 60 grams of pure alcohol (men) or 40 grams (women).

    Time frame: month 3

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Study locations

1 site
  • Centre Hospitalier Henri Laborit
    Poitiers, 86021, France
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References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 22, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05341934
Lead sponsor
Centre Hospitalier Henri Laborit
Responsible party
Sponsor
First posted
Apr 22, 2022
Start date
Jan 15, 2018
Primary completion
Dec 30, 2019
Completion
Dec 30, 2019
Last update
Apr 22, 2022

Study contacts

JAAFARI NEMATOLLAH, PROFESSOR
principal investigator · Centre Hospitalier Henri Laborit

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.

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