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RecruitingNCT058436043TOCUpdated Jan 13, 2026

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

An observational study in OCD, sponsored by Centre Hospitalier Henri Laborit. Recruiting at 1 site in France. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-13.

Sponsored by Centre Hospitalier Henri Laborit · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
100
Ages
18 Years to 70 Years
Sex
All
01

Study summary

This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.

02

Conditions studied

  • OCD

Keywords

  • functional MRI
03

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Patients will be recruited from the Clinical Research Unit of Poitiers. All volunteer patients included in this study will be included regardless of the degree of resistance to treatment or the severity of their disease. Patients will not be hospitalized for the duration of the study unless their condition requires it.

Healthy volunteers will be recruited locally by advertisement or through acquaintances, and will be matched to each patient based on age, gender, laterality, and education level. They must not have an acute pathology being treated, nor take psychotropic drugs, nor be followed in psychotherapy. In their history, we must not find hospitalization in a psychiatric environment or a psychiatric illness according to the M.I.N.I. version 5.0.0.

Inclusion criteria

  • Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
  • Understand and accept the constraints of the study
  • Be a beneficiary or affiliated to a Health Insurance scheme

Exclusion criteria

Exclusion Criteria:

  • Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
  • Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
  • Have a serious intercurrent pathology
  • Being a pregnant woman
  • Being a woman of childbearing age without effective contraception.
  • Being hospitalized under duress or on an outpatient basis in a care program
  • Being under judicial protection (reinforced curatorship, guardianship)
04

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No

Groups and cohorts

  • obsessive compulsive disorder patients

    Other: Functional MRI

  • Control Patients

    Other: Functional MRI

Interventions

  • OtherFunctional MRI

    Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task

05

What researchers measure

Primary outcomes

  1. Cerebral activity modification during N-back task

    Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

    Time frame: Day 1

  2. Cerebral activity modification during Stroop task

    Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

    Time frame: Day 1

  3. Cerebral activity modification during switching task (Monsell et Mizon task )

    Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

    Time frame: Day 1

06

Study locations

1 of 1 sites recruiting
  • Centre Hospitalier Henri Laborit
    Poitiers, France
    • Damien Doolub, MD · Contact
    Recruiting
07

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT05843604
Lead sponsor
Centre Hospitalier Henri Laborit
Responsible party
Sponsor
First posted
May 6, 2023
Start date
Jul 3, 2023
Primary completion
Jul 2027 (estimated)
Completion
Sep 2027 (estimated)
Last update
Jan 13, 2026

Study contacts

Damien Doolub, MD
Contact
damien.doolub@ch-poitiers.fr
+33 (0)5 16 61 18

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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