Ultrasound Guided Steroids Injection Versus PRP for Shoulder Pain Relief

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• Shoulder Pain 707

Shoulder Pain

707 studies on the registry are indexed under Shoulder Pain; 152 are open to participants now.

This study's enrollment of 60 is close to the median of 60 across 561 interventional studies indexed under Shoulder Pain.

Lead sponsor

Alexandria University is the lead sponsor of 569 studies on the registry; 125 are open to participants now.

Of its 12 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Study arms

• Experimental
  Platelet rich plasma group

  participants will receive Ultrasound guided subacromial injection of 3 ml platelet rich plasma+0.5 ml of PRP activator (10% calcium gluconate)+ 1ml 0.5%bupivacaine.

  Combination Product: Platelet rich plasma

• Experimental
  Methylprednisolone group

  participants will receive Ultrasound guided subacromial injection of 1 ml methylprednisolone+ 1ml 0.5%bupivacaine + 2.5 ml normal saline.

  Combination Product: Methylprednisolone

Interventions

• Combination productPlatelet rich plasma

  platelet rich plasma will be obtained from the particepants own blood mixed with activator and bupivacaine

  Also known as: PRP group

• Combination productMethylprednisolone

  1ml methyl prednisolone 40mg\\ml mixed with normal saline and bupivacaine

  Also known as: steroids group

Primary outcomes

1. Shoulder pain assesment

   The pain will be assessed using visual analogue scale( score range=0-10,less than 4,4-6 and more than 6 for mild, moderate and severe pain respectively)

   Time frame: 4 months

Secondary outcomes

1. Assesment of rotator cuff tendon healing

   assesment healing process of tendon using ultrasound technique

   Time frame: 4 months

2. Assesment the failure rate after shoulder joint injection

   failure of relief the symptoms after shoulder joint injection will be recorded

   Time frame: 4 months

3. The reinjection rate recording

   the incidence of reinjection the shoulder joint due to inadequate pain relief will be recorded

   Time frame: 4 months

4. Assesment the rate of tear recurrence after shoulder joint injection

   The rate of tear recurrence after 4 months of injection will be assessed using MRI or US

   Time frame: 4 months

5. Simple shoulder assessment test

   Functional assessment of shoulder joint will be done using simple sholder assessment test 0= maximal disability 20% -40% = crippled 40% -60% = severe disability 60% -80% = moderate disability 100% = no disability

   Time frame: 4 months

Other outcomes

1. Measurement plasma C-Reactive Protein level

   The plasma C- Reactive Protein level will be measured prior to injection and 4 months later on after the procedure

   Time frame: 4 months

2. Measurement the fasting blood glucose level

   The fasting blood glucose level will be measure prior to and one week later after injection

   Time frame: one week

3. Assesment the complications after shoulder joint injection

   Complications that might occur after shoulder joint injection such as infection, elevated blood sugar, allergy, nerve injury, nausea and vomiting will be recorded

   Time frame: 4 months

4. Measurement the serum cortisol level

   Early morning(8 am serum cortisol level) will be measured before the injection and one week later after injection

   Time frame: one week