An observational study in Traumatic Brain Injury, sponsored by Tang-Du Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-03-31.
Sponsored by Tang-Du Hospital · Observational
The purpose of this study was to observe the relationship between the changes of circulating extracellular vesicles and disease development and outcome in patients with traumatic brain injury, and to find early serum markers and potential intervention targets for disease monitoring in patients with traumatic brain injury. In addition, explore the source of extracellular vesicles as much as possible to prepare for subsequent basic experiments.
To compare the changes of molecular markers and circulating-related cell phenotype molecules in the serum of patients with traumatic brain injury, to observe the relationship between the changes of circulating extracellular vesicles and the development and outcome of the disease in patients with traumatic brain injury, and to search for early serum markers of patients with traumatic brain injury and potential interventions.
2,114 studies on the registry are indexed under Brain Injuries; 386 are open to participants now.
This study's planned enrollment of 300 is above the median of 100 across 690 observational studies indexed under Brain Injuries.
Browse Brain Injuries studies →Tang-Du Hospital is the lead sponsor of 164 studies on the registry; 77 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All TBI patients treated at Tangdu Hospital from January 2022 to December 2022
Exclusion Criteria:
The type and content of circulating extracellular vesicles
After isolation of circulating extracellular vesicles, RNA sequencing was performed to determine noncoding RNA changes in circulating extracellular vesicles. Screening criteria were based on logFC and P value, generally with \|logFC\|\>2 and AP value \<0.05 to define whether there was a difference.
Time frame: within 24 hours of TBI
Neurological deterioration in patients with traumatic brain injury
Neurological deterioration (ND) was defined as the occurrence of one or more of the following criteria within 7 days after injury: (a) a decrease in GCS score of 2 points or more from the initial GCS score with no pharmacological sedation; (b) a deterioration in neurological status being sufficient to neurosurgical intervention.
Time frame: within 7 days after injury
hospital stay
The cumulative number of days from admission to discharge of the patient. Regardless of whether the admission and discharge were in the morning or afternoon, the total admission and discharge was one day. It mainly reflects the turnover of hospital beds.
Time frame: From hospitalization to discharge，up to one month
GOSE score
The GOSE score was dichotomized into being moderately disabled or worse (GOSE score ≤6) versus good recovery (GOSE score 7-8), and into being severely disabled or worse (GOSE score ≤4) versus moderate or no disability (GOSE score 5-8).
Time frame: three months or six months
This study is status unknown, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.
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Tang-Du Hospital