An observational study in Long QT Syndrome, Brugada Syndrome and Cardiac Conduction System Disease, sponsored by Centre Hospitalier Universitaire de la Réunion. Completed at 1 site in Reunion. Open to participants aged 12 Years and older. Per ClinicalTrials.gov, last updated 2025-08-05.
Sponsored by Centre Hospitalier Universitaire de la Réunion · Observational
In patients expressing the SCN5A-E1784K mutation (Glu1784Lys), cardiovascular risk is difficult to define as the stratification of these patients is challenging. From our experience, major cardiovascular events (MCE) tend to occur more frequently in patients expressing overlap syndrome phenotype (Brugada syndrome and Long QT syndrome type 3)than in patients expressing a single phenotype (whether Brugada syndrome or Long QT syndrome type 3). This trials is led on the impact on Risk Stratification of Overlap Syndrome Phenotype in Patients With E1784K Mutation in SCN5A ( RISKOVER )
Study design: This study will compare the occurrence of MCE between patients with overlap syndrome phenotype and patients with a single phenotype (whether Brugada syndrome or Long QT syndrome type 3) in a cohort of patients 12 years of age and older with the SCN5A-E1784K mutation. Eligible patients will be identified nationwide and included retrospectively and prospectively. Occurrence of MCE between the group " overlap syndrome " and the group " single phenotype " will be compared.
95 studies on the registry are indexed under Long QT Syndrome; 20 are open to participants now.
This study's enrollment of 47 is below the median of 150 across 48 observational studies indexed under Long QT Syndrome.
Browse Long QT Syndrome studies →Centre Hospitalier Universitaire de la Réunion is the lead sponsor of 137 studies on the registry; 35 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients with hereditary cardiac disease
Exclusion Criteria:
Occurrence of MCE
occurrence of syncop, sudden cardiac death, ventricular arrhythmia, cardiopulmonary arrest collected by a series of medical questions
Time frame: at inclusion
Plan to share: No
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This study is completed, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire de la Réunion