An interventional study of Peppermint oil vapors and Mineral Oil in Urinary Retention, sponsored by TriHealth Inc.. Terminated at 1 site in United States. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-08-29.
Sponsored by TriHealth Inc. · Not applicable, Interventional, and Treatment
A randomized controlled study will be conducted, with two arms. Postpartum women experiencing urinary retention will be randomized into one of the two following arms:
The purpose of the study is to determine if the use of peppermint oil among postpartum women experiencing urinary retention will increase spontaneous urination and decrease the need for catheterization. A randomized controlled study will be conducted, with two arms. Subjects will be randomized into one of the two following arms:
235 studies on the registry are indexed under Urinary Retention; 39 are open to participants now.
This study's enrollment of 17 is below the median of 95 across 185 interventional studies indexed under Urinary Retention.
Browse Urinary Retention studies →TriHealth Inc. is the lead sponsor of 99 studies on the registry; 9 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 4 (44%) have results posted.
Counted across the registry records on this site, refreshed daily.
1. 18 years old or older 2. English speaking 3. Admitted to Bethesda North Mom Baby Unit 4. Postpartum 5. Experiencing urinary retention - defined as meeting at least one of the following criteria:
Exclusion Criteria:
Subjects will be exposed to vapor of peppermint oil
Other: Peppermint oil vapors
Subjects will be exposed to vapor of placebo (mineral oil)
Other: Mineral Oil
Subjects will be exposed to vapor of peppermint oil
Subjects will be exposed to vapor of placebo (mineral oil)
Percent of Patients With Urinary Retention Resolved
Urinary retention defined as: * More than 6 hours after delivery or foley catheter removal without being able to spontaneously void * Symptomatic urinary retention without being able to spontaneously void * Change in fundal height or position without being able to spontaneously void More than 6 hours after delivery or foley catheter removal without voiding spontaneously; symptomatic urinary retention without being able to spontaneously void; or change in fundal height or position without being able to spontaneously void Resolution of urinary retention will be achieved if patient spontaneously voids within 10 minutes after exposure to oil
Time frame: 10 minutes
Time to Spontaneous Urination
Minutes until participant spontaneously voids
Time frame: 1 hour
Volume of Spontaneous Urination
Volume of urine when participant spontaneously voids
Time frame: 1 hour
Incidence of Urinary Catheterization
Whether participant requires urinary catheterization or not
Time frame: 1 hour
Patient Satisfaction
Patient rated satisfaction
Time frame: 1 hour
| Milestone | Peppermint Oil | Placebo |
|---|---|---|
| Started | 10 | 7 |
| Completed | 10 | 7 |
| Not completed | 0 | 0 |
Urinary retention defined as: * More than 6 hours after delivery or foley catheter removal without being able to spontaneously void * Symptomatic urinary retention without being able to spontaneously void * Change in fundal height or position without being able to spontaneously void More than 6 hours after delivery or foley catheter removal without voiding spontaneously; symptomatic urinary retention without being able to spontaneously void; or change in fundal height or position without being able to spontaneously void Resolution of urinary retention will be achieved if patient spontaneously voids within 10 minutes after exposure to oil
| Participants | Peppermint Oil | Placebo |
|---|---|---|
| Percent of Patients With Urinary Retention Resolved | 3 | 1 |
Minutes until participant spontaneously voids
Results for this outcome have not been posted.
Volume of urine when participant spontaneously voids
Results for this outcome have not been posted.
Whether participant requires urinary catheterization or not
Results for this outcome have not been posted.
Patient rated satisfaction
Results for this outcome have not been posted.
Collected over from enrollment until end of follow-up, up to 2 days. Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Peppermint Oil | 0/10 (0%) | 0/10 (0%) | 0/10 (0%) |
| Placebo | 0/7 (0%) | 0/7 (0%) | 0/7 (0%) |
| Age, Categorical(Participants) | Peppermint Oil | Placebo | Total |
|---|---|---|---|
| <=18 years | 0 | 0 | 0 |
| Between 18 and 65 years | 10 | 7 | 17 |
| >=65 years | 0 | 0 | 0 |
| Sex: Female, Male(Participants) | Peppermint Oil | Placebo | Total |
|---|---|---|---|
| Female | 10 | 7 | 17 |
| Male | 0 | 0 | 0 |
| Race and Ethnicity Not Collected(Participants) | Peppermint Oil | Placebo | Total |
|---|---|---|---|
| Count of participants | — | — | 0 |
Documents are hosted by the registry — open the source record to download them.
Plan to share: No
This study is terminated, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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TriHealth Inc.