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Enrolling by invitationNCT06370702Updated Oct 13, 2026

Evaluating the Use of Grip Exercises to Decrease Deep Vein Thrombosis in Adult Patients With PICC Lines

An interventional study of Handgrip Exercises in Deep Vein Thrombosis, sponsored by TriHealth Inc.. Enrolling by invitation at 2 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-13.

Sponsored by TriHealth Inc. · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
2,500
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

Patients who have a peripherally-inserted central catheter (PICC) placed are at a risk of developing a deep vein thrombosis (DVT). At TriHealth, approximately 2-4 patients per month who have a PICC placed experience a subsequent DVT. One innovative way to possibly mitigate the risk of DVTs is hand grip exercises. The current study will be the first study to evaluate hand grip exercises for the prevention of DVTs in adult patients hospitalized in the United States.

02

Conditions studied

  • Deep Vein Thrombosis

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03

In context

Venous Thrombosis

785 studies on the registry are indexed under Venous Thrombosis; 110 are open to participants now.

This study's planned enrollment of 2,500 is above the median of 152 across 477 interventional studies indexed under Venous Thrombosis.

Browse Venous Thrombosis studies →

Lead sponsor

TriHealth Inc. is the lead sponsor of 102 studies on the registry; 9 are open to participants now.

Of its 9 completed or terminated interventional studies of FDA-regulated products, 4 (44%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Had a PICC placed in the past 24 hours by the Vascular Access Team
  • Patient is admitted to either Bethesda North Hospital or Good Samarian Hospital

Exclusion criteria

Exclusion Criteria:

  • Under 18 years old
  • Does not speak English
  • Unable to consent to involvement in the research study
  • Has a bleeding disorder/diagnosis
  • Has a severe limb disfunction whereby they would be unable to perform the grip exercises
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
2,500 participants (estimated)

Study arms

  • Experimental
    Handgrip Exercise Group

    Participants will be instructed to firmly grip and squeeze the ball for 10 seconds, relax for 10 seconds and repeat for 10 minutes. They will be instructed to do this 3 times per day.

    Other: Handgrip Exercises

  • No intervention
    Standard Care Group

    Participants will receive standard care that includes no instruction about conducting hand grip exercises.

Interventions

  • OtherHandgrip Exercises

    Participants will firmly grip and squeeze the ball for 10 seconds, relax for 10 seconds and repeat for 10 minutes. They will be instructed to do this 3 times per day.

06

What researchers measure

Primary outcomes

  1. Deep vein thrombosis

    Incidence of deep vein thrombosis

    Time frame: from PICC placement to PICC removal, up to 4 weeks

07

Study locations

2 sites
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

1 registry update since Sep 25, 2026
Minor edits
Nothing that changes what the study is or who can join. Edited: verification date
1 update, last Oct 13, 2026
Show all 1 update
  1. Oct 13, 2026
    Minor edits only
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT06370702
Lead sponsor
TriHealth Inc.
Responsible party
Sponsor
First posted
Apr 17, 2024
Start date
Oct 6, 2023
Primary completion
May 31, 2027 (estimated)
Completion
Dec 30, 2027 (estimated)
Last update
Oct 13, 2026

Study contacts

Rachel Baker, PhD, RN
study chair · TriHealth Nurse Researcher

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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