An interventional study of Polycamomile Lidocaine Gel and Lidocaine Glue in Postoperative Sore Throat, sponsored by The Second Affiliated Hospital of Chongqing Medical University. Not yet recruiting at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by The Second Affiliated Hospital of Chongqing Medical University · Not applicable, Interventional, and Prevention
Total anesthesia is the most commonly used anesthesia method in clinical surgery, which can reduce hospital stay and improve patient comfort on the basis of ensuring patient surgery safety. However, for patients with total anaesthetic tracheotomy, the incidence of throat complications such as throat pain, wheezing, and coughing after tracheotomy removal remains high. According to literature reports, the incidence of throat pain can reach 40% after total anaesthetic tracheotomy removal, the incidence of wheezing is 24%, and the related throat symptoms can persist until 24 hours or even longer after surgery. This phenomenon is particularly notable in patients with thoracic surgery.The high incidence of laryngeal pain after thoracic surgery is the result of the combination of mechanical stimulation of the bronchial / bilateral bronchial catheter, air sac pressure, surgery time and position, individual susceptibility factors of the patient, and technical details of intubation/entubation. Although such laryngeal complications are milder compared to other anesthetic complications, they can reduce the patient's post-operative hospitalization comfort and satisfaction, and even prolong the hospitalization time, affecting clinical treatment effectiveness and patient admission experience.This study aims to explore the effect of polycamomile lidocaine gel as a bronchial catheter lubricant on postoperative laryngeal complications in patients undergoing thoracic surgery. It aims to provide new ideas and clinical basis for optimizing clinical drug administration protocols and reducing the incidence of postoperative laryngeal complications for patients undergoing thoracic surgery with total anaesthetic bronchial intubation.
The Second Affiliated Hospital of Chongqing Medical University is the lead sponsor of 102 studies on the registry; 32 are open to participants now.
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The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
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You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Drug: Polycamomile Lidocaine Gel
Drug: Lidocaine Glue
2 g of polycamomile lidocaine gel was uniformly applied from the tip of the tracheal tube to 1/3 of the front
Uniformly apply 2g lidocaine glue from tip to front 1/3 of the end of the tracheal tube
Baseline-corrected delta in CPPS (dB) for the sustained vowel /ɑ/ stable segment at 6 hours post-extubation (ΔCPPS₆ₕ = CPPS₆ₕ - CPPSₚᵣₑ)
Time frame: Six hours after extubation
The ΔCPPS values at 1, 24, and 48 hours after extubation
Time frame: 1 hour, 24 hours and 48 hours after the removal of the tracheal tube
After extubation, the laryngoscope was used to grade the throat condition; the incidence of throat pain and cough was related to the grade.
Time frame: 1 hour, 24 hours, and 48 hours after extubation
Plan to share: No
Start is estimated for Oct 2026; primary completion for Dec 2027, 14 months later.
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This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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