An interventional study of Interventions in Mathematics and Cognitive Skills - Experimental and Interventions in Mathematics and Cognitive Skills - Active Comparator in Math Learning Disability, Child Development and Developmental Disability, sponsored by Stanford University. Recruiting at 1 site in United States. Open to participants aged 6 Years to 12 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-11.
Sponsored by Stanford University · Not applicable, Interventional, and Treatment
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).
To achieve this goal, investigators will use a theoretically-motivated integrated symbolic/non-symbolic (iSNS) intervention with a randomized controlled design to enhance cross-format mapping between symbolic and nonsymbolic representations of quantities. The investigators will develop innovative computational models to investigate individual differences in latent cognitive processes and brain plasticity that contribute to learning, long-term retention, and transfer in children.
The investigators will assess performance in several areas and investigate cognitive and neural mechanisms that support numerical skill acquisition in children with differing levels of math learning abilities.
230 studies on the registry are indexed under Developmental Disabilities; 65 are open to participants now.
This study's planned enrollment of 180 is above the median of 60 across 150 interventional studies indexed under Developmental Disabilities.
Browse Developmental Disabilities studies →Stanford University is the lead sponsor of 2,168 studies on the registry; 431 are open to participants now.
Of its 267 completed or terminated interventional studies of FDA-regulated products, 207 (78%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Integrative symbolic non-symbolic (iSNS) training: Over a period of 6 weeks, participants will complete activities that progressively strengthen the mapping of symbolic numerical representations to non-symbolic numerical quantities and enhance fluency in symbolic numerical skills.
Other: Interventions in Mathematics and Cognitive Skills - Experimental
Active control intervention: Over a period of 6 weeks, participants will complete activities that enhance short-term storage and maintenance of visuospatial or verbal information.
Other: Interventions in Mathematics and Cognitive Skills - Active Comparator
After study participants have completed screenings to meet our inclusion criteria, participants will take part in the pre-training MRI brain scan (if eligible) and behavioral assessments and will then be assigned to the intervention for 6 weeks. During this training, participants will spend three days each week completing a set of problems at their home on a tablet that we provide them. Participants will receive one-to-one training with a member of our research team once a week. Following the completion of the 6-week training program, participants will be asked to complete a second MRI brain imaging session (for those who completed pre-training MRI) and post-measure appointments in order to assess immediate effects of the training program. Participants will also be invited to return for follow-up testing after six months in order to assess the long- lasting effects of the training program.
After study participants have completed screenings to meet our inclusion criteria, participants will take part in the pre-training MRI brain scan (if eligible) and behavioral assessments and will then be assigned to the intervention for 6 weeks. During this training, participants will spend three days each week completing a set of problems at their home on a tablet that we provide them. Participants will receive one-to-one training with a member of our research team once a week. Following the completion of the 6-week training program, participants will be asked to complete a second MRI brain imaging session (for those who completed pre-training MRI) and post-measure appointments in order to assess immediate effects of the training program. Participants will also be invited to return for follow-up testing after six months in order to assess the long- lasting effects of the training program.
Change from baseline in symbolic number comparison task performance (reaction time)
Performance will be measured by children's reaction time (milliseconds) on symbolic number comparison task
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in symbolic number comparison task performance (accuracy)
Performance will be measured by children's accuracy (% trials correct) on symbolic number comparison task
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in non-symbolic number comparison task performance (reaction time)
Performance will be measured by children's reaction time (milliseconds) on non-symbolic number comparison task
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in non-symbolic number comparison task performance (accuracy)
Performance will be measured by children's accuracy (% trials correct) on non-symbolic number comparison task
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in latent cognitive measures of symbolic number comparison task performance (drift rate)
Latent cognitive processing will be measured by drift rate from children's symbolic number comparison task performance
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in latent cognitive measures of symbolic number comparison task performance (post-error adjustment)
Latent cognitive processing will be measured by post-error adjustment from children's symbolic number comparison task performance
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in latent cognitive measures of non-symbolic number comparison task performance (drift rate)
Latent cognitive processing will be measured by drift rate from children's non-symbolic number comparison task performance
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in latent cognitive measures of non-symbolic number comparison task performance (post-error adjustment)
Latent cognitive processing will be measured by post-error adjustment from children's non-symbolic number comparison task performance
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in brain activation during symbolic number comparison task performance
Neural activity will be measured during functional magnetic resonance imaging (fMRI) symbolic number comparison task. Data will consist of beta values from individual subject contrast maps for Near vs Far contrast from the whole-brain GLM fMRI analysis.
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in brain activation during non-symbolic number comparison task performance
Neural activity will be measured during functional magnetic resonance imaging (fMRI) non-symbolic number comparison task. Data will consist of beta values from individual subject contrast maps for Near vs Far contrast from the whole-brain general linear model (GLM) fMRI analysis.
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in symbolic addition task performance (reaction time)
Performance will be measured by children's reaction time (milliseconds) on symbolic addition task
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in symbolic addition task performance (accuracy)
Performance will be measured by children's accuracy (% trials correct) on symbolic addition task
Time frame: Baseline and post-intervention (after 6 weeks)
Plan to share: No
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Started May 2023 (actual). Primary completion is estimated for Aug 2027, 51 months after the start.
Of 96 non-industry interventional studies with no phase under Developmental Disabilities, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 49. This study's planned 51 months is above that.
Counting every sponsor, half of 97 studies reached it within 22 months; a quarter within 13 and three quarters within 49.
How these figures are worked out, and which studies are left out of them.
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