A Phase 4 interventional study of Aspirin 100mg; Clopidogrel 300mg in Ischemic Stroke, sponsored by General Hospital of Shenyang Military Region. Completed at 2 sites in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-10-31.
Sponsored by General Hospital of Shenyang Military Region · Phase 4, Interventional, and Treatment
The current guideline recommends to give antithrombotic treatment 24 hours after intravenous thrombolysis in acute ischemic stroke. However, early neurological deterioration will occur in some patients due to no antithrombotic treatment, which is closely associated with poor outcome. The current trial aims to investigate the effectiveness and safety of early antithrombotic treatment after intravenous thrombolysis in minor stroke.
7,283 studies on the registry are indexed under Stroke; 2,013 are open to participants now.
This study's enrollment of 1,022 is above the median of 50 across 5,366 interventional studies indexed under Stroke.
Browse Stroke studies →General Hospital of Shenyang Military Region is the lead sponsor of 78 studies on the registry; 33 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
aspirin 100mg plus clopidogrel 300mg
Drug: Aspirin 100mg; Clopidogrel 300mg
aspirin placebo plus clopidogrel placebo
Drug: Aspirin 100mg; Clopidogrel 300mg
Aspirin 100mg plus Clopidogrel 300mg will be orally administrated after randomization
The proportion of excellent prognosis
excellent prognosis is defined as modified Rankin Score (mRS) 0-1. The minimum and maximum values of mRS are 0 and 6, respectively; higher score mean a worse outcome
Time frame: Day 90
The proportion of favorable prognosis
Favorable prognosis is defined as modified Rankin Score (mRS) 0-2. The minimum and maximum values of mRS are 0 and 6, respectively; higher score mean a worse outcome.
Time frame: Day 90
Distribution of modified Rankin Score (mRS)
The minimum and maximum values of mRS are 0 and 6, respectively; higher score mean a worse outcome.
Time frame: Day 90
Changes in National Institute of Health stroke scale (NIHSS)
the minimum and maximum values of NIHSS are 0 and 42, respectively; higher NIHSS mean a worse outcome.
Time frame: 24 hours, 48 hours, and 10 days
Occurrence of early neurologyical deterioration (END)
END is defined as more than 2 point increase, but not result of cerebral hemorrhage, compared with baseline at 24 hours
Time frame: 24 hours
The incidence of symptomatic intracerebral hemorrhage
any evidence of bleeding on the head CT scan associated with clinically significant neurological deterioration (NIHSS score ≥4 points increase)
Time frame: 36 hours
The incidence of any intracerebral hemorrhage
the evidence of bleeding on the head CT or MRI scan
Time frame: 36 hours
The incidence of stroke recurrence and other vascular events
Time frame: Day 90
The death due to any cause
Time frame: Day 90
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Oct 2024. You cannot join it, but the record below documents what was studied.
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General Hospital of Shenyang Military Region