An observational study in Neuroimaging, Cognitive Dysfunction and Posterior Reversible Encephalopathy Syndrome, sponsored by Dunjin Chen. Status unknown at 1 site in China. Open to female participants aged 15 Years to 60 Years. Per ClinicalTrials.gov, last updated 2021-12-08.
Sponsored by Dunjin Chen · Observational
The purpose of this study is to explore the long-term consequences of neuroimaging and perceived cognitive dysfunction in obstetrics posterior reversible encephalopathy syndrome.
This is a prospective study. The investigators divided the PE or E patients into two groups, namely PRES group and non-PRES group, according to diagnostic criteria . The general information（demographic data，blood pressure.etc.）and blood sample will be collected. Additionally,all patients receive neuroimaging examination（DTI,ASL,3D-TMI.etc.）and neuro-cognitive test（MMSE,MOCA,CFQ, etc.） to assess the cerebral white matter lesions and cognitive changes.
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We divided the PE or E patients into two groups, namely PRES group and non-PRES group, according to diagnostic criteria . the general information（demographic data，blood pressure.etc.）and blood sample will be collected.
Exclusion Criteria:
PE or E with PRES
Biological: neuroimaging examination,neuro-cognitive test,blood pressure,blood sample
PE or E without PRES
Biological: neuroimaging examination,neuro-cognitive test,blood pressure,blood sample
neuroimaging will be perform,neuro-cognitive will be tested,blood pressure will be monitored,blood samples will be tested
neuroimaging examination
the degree of white matter lesions(0,normal; 1, limited cortical or subcortical white matter oedema; 2, white matter oedema \> cortical oedema, white matter oedema extending into deep white matter; 3, white matter oedema \> cortex oedema, oedema extending to the ventricular surface; 4, the involved regions substantially extend to the ventricular surface and are almost completely confluent; 5, involved regions are fully confluent and continuous, ventricular deformity due to the oedema).The value of fractional anisotropy(FA) in PRES group may higher than non- PRES group, and mean diffusivity (MD) in PRES group may lower than non- PRES group.
Time frame: within 10 years after deliver
neuro-cognitive test of Mini-mental State Examination
the scores of Mini-mental State Examination,normal (27-30);mild (21-26); moderate (10-20); severe (0-9).
Time frame: within 10 years after deliver
neuro-cognitive test of Montreal Cognitive Assessment
the scores of Montreal Cognitive Assessment,normal (≥26); abnormal (\<26).
Time frame: within 10 years after deliver
blood pressure and hypertension
Hypertension: blood pressure ≥140/90 mmHg
Time frame: within 10 years after deliver
level of lactate dehydrogenase(LDH)
inflammatory: LDH\>380U/L
Time frame: within 10 years after deliver
level of LDL in blood
hyperlipidemia：LDL\>3.12mmol/L
Time frame: within 10 years after deliver
Plan to share: No
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This study is status unknown, as verified in Nov 2021. You cannot join it, but the record below documents what was studied.
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Dunjin Chen