An interventional study of Indomethacin suppository and Standard Medical Treatment in Pancreatoduodenectomy, sponsored by Institute of Liver and Biliary Sciences, India. Completed at 1 site in India. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2022-07-06.
Sponsored by Institute of Liver and Biliary Sciences, India · Not applicable, Interventional, and Prevention
Pancreatico-duodenectomy is one of the commonly performed procedure for periampullary/distal cholangio/head of pancreas carcinoma. Post operative pancreatitis is an emerging concept, recently being studied as one of the most important contributing factor of Post-operative pancreatic fistula, which is one of the major complication of pancreatoduodenectomy. Rectal indomethacin, a type of non-steroidal anti-inflammatory drug, when given in a single dose has been shown to prevent pancreatitis in patients undergoing ERCP. In this study, we will be administering rectal indomethacin at the time of induction of anesthesia to the experimental arm of the study and compare the results in terms of incidence of post-operative pancreatitis in the two groups.
752 studies on the registry are indexed under Pancreatitis; 181 are open to participants now.
This study's enrollment of 44 is below the median of 80 across 448 interventional studies indexed under Pancreatitis.
Browse Pancreatitis studies →Institute of Liver and Biliary Sciences, India is the lead sponsor of 296 studies on the registry; 84 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Standard Medical Treatment
Other: Standard Medical Treatment
Will be administered 100mg of Indomethacin Suppository sigle dose at the time of induction of anesthesia with Standard Medical Treatment
Drug: Indomethacin suppository · Other: Standard Medical Treatment
100mg Indomethacin Suppository administered at the time of Induction
Standard Medical Treatment
Post-operative Pancreatitis
Time frame: first 30 days following pancreatoduodenectomy
Post-operative Pancreatic Fistula
Time frame: first 30 days following pancreatoduodenectomy
delayed gastric emptying
Time frame: First 30 days following pancreatoduodenectomy
intra-abdominal abscess
Time frame: first 30 days following pancreatoduodenectomy
Length of ICU stay
Time frame: First 30 days following pancreatoduodenectomy
Length of hospital stay
Time frame: First 30 days following pancretoduodenectomy
risk factors of post-operative pancreatitis
Time frame: first 30 days following pancreatoduodenectomy
Plan to share: No
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This study is completed, as verified in Oct 2021. You cannot join it, but the record below documents what was studied.
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Institute of Liver and Biliary Sciences, India