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CompletedNCT05092737Updated Jun 3, 2022

Physiological Response to Prone Position in COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)

An observational study in ARDS and Sars-CoV-2 Infection, sponsored by University of Lausanne Hospitals. Completed at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-06-03.

Sponsored by University of Lausanne Hospitals · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
31
Ages
18 Years and older
Sex
All
01

Study summary

Retrospective study in COVID-19 ARDS patients hospitalised in the ICU. Investigators aim to explore the effects of prone positioning on oxygenation, dead space ventilation and mortality.

02

Conditions studied

  • ARDS
  • Sars-CoV-2 Infection
03

In context

COVID-19

7,641 studies on the registry are indexed under COVID-19; 487 are open to participants now.

This study's enrollment of 31 is below the median of 261 across 3,136 observational studies indexed under COVID-19.

Browse COVID-19 studies →

Lead sponsor

University of Lausanne Hospitals is the lead sponsor of 118 studies on the registry; 9 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

COVID-19 moderate to severe ARDS patients who sustained prone positioning

Inclusion criteria

  • COVID-19 associated moderate to severe ARDS
  • Invasive mechanical ventilation
  • Prone positioning
  • admitted to ICU

Exclusion criteria

Exclusion Criteria:

  • already sustained prone positioning in referring hospital
  • pronation during ECMO only
  • denied consent for data analysis
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
31 participants (actual)
Patient registry
No

Interventions

  • ProcedureProne positioning

    Prone position during invasive mechanical ventilation

06

What researchers measure

Primary outcomes

  1. PaO2/FiO2

    Arterial partial pressure of oxygen / Fraction of inspired oxygen

    Time frame: Within 2 hours before pronation and 2 hours before supination

Secondary outcomes

  1. Alveolo-arterial oxygen gradient change

    Time frame: Within 2 hours before pronation and 2 hours before supination

  2. Ventilatory Ratio

    Time frame: Within 2 hours before pronation and 2 hours before supination

  3. Mortality or Extracorporeal membrane oxygenation (ECMO) support

    Time frame: Once between ICU admission and extubation

07

Study locations

1 site
  • Lausanne University Hospitals
    Lausanne, Vaud 1011, Switzerland
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 3, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05092737
Lead sponsor
University of Lausanne Hospitals
Responsible party
Piquilloud Imboden Lise (Principal Investigator, University of Lausanne Hospitals) — Principal investigator
First posted
Oct 25, 2021
Start date
Aug 1, 2021
Primary completion
Apr 30, 2022
Completion
Apr 30, 2022
Last update
Jun 3, 2022

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2021. You cannot join it, but the record below documents what was studied.

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Discussion

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