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CompletedNCT05076929Updated Oct 3, 2022

Assessment of Ultrasonographic Measurement of Inferior Vena Cava Collapsibility Index in Prediction of Hypotension Associated With Tourniquet Release in Total Knee Replacement Surgeries Under Spinal Anesthesia

An observational study in Fluid Hypovolemia, Cerebrospinal, sponsored by Ain Shams University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2022-10-03.

Sponsored by Ain Shams University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
60
Ages
18 Years to 65 Years
Sex
All
01

Study summary

Administration of intravascular fluids is one of the methods to prevent SA-induced hypotension, but empirical intraoperative volume repletion carries the risk of fluid overload during elective surgery. Over fluid resuscitation is associated with organ dysfunction and higher mortality rate , thus, to avoid ineffective or even harmful intravascular volume expansion, it is important to have tools to predict hypotension and fluid responsiveness.

02

Conditions studied

  • Fluid Hypovolemia, Cerebrospinal
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In context

Hypotension

1,003 studies on the registry are indexed under Hypotension; 173 are open to participants now.

This study's enrollment of 60 is below the median of 84 across 294 observational studies indexed under Hypotension.

Browse Hypotension studies →

Lead sponsor

Ain Shams University is the lead sponsor of 1,876 studies on the registry; 423 are open to participants now.

Of its 32 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Total Knee Replacement Surgeries under Spinal Anesthesia

Inclusion criteria

  • ASA grade I, II, III
  • Age 18 -65 yrs
  • Spinal Anesthesia

Exclusion criteria

Exclusion Criteria:

  • Patient refusal
  • Patient having contraindication of Spinal Anesthesia (infection at the site of injection, spine deformity, coagulation disorders ) .
  • Known cardiac, renal, neurological, metabolic, endocrine, psychiatric, respiratory disease.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
60 participants (actual)
Patient registry
No

Interventions

  • Diagnostic testultrasound

    Ultrasonographic measurement of Inferior Vena Cava Collapsibility Index

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What researchers measure

Primary outcomes

  1. mean arterial blood pressure

    Time frame: 15 minutes after tourniquet release

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Study locations

1 site
  • Ain Shams University
    Cairo, Egypt
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 3, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05076929
Lead sponsor
Ain Shams University
Responsible party
Mona Ammar (Assistant Professor, Ain Shams University) — Principal investigator
First posted
Oct 13, 2021
Start date
May 28, 2021
Primary completion
Feb 1, 2022
Completion
Mar 1, 2022
Last update
Oct 3, 2022

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2022. You cannot join it, but the record below documents what was studied.

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