ClinicalTrials.gg
CompletedNCT07757971Updated Oct 13, 2026

2D:4D Ratio in Relation to Anxiety and Stress Among Anesthesiology Residents

An observational study in Anxiety and Stress, sponsored by Ain Shams University. Completed at 1 site in Egypt. Open to participants aged 20 Years to 35 Years. Per ClinicalTrials.gov, last updated 2026-10-13.

Primary conditionAnxiety Disorders(the registry's first term)UnverifiedIs this wrong?The registry often attaches Anxiety Disorders to studies about something else, and this study's title and listed conditions do not name it. No better condition is named, so the registry's term is kept.

Sponsored by Ain Shams University · Observational

Updated Oct 13, 2026Now CompletedNow Recruiting+6 moreGo to Updates ↓

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Study type
Observational
Model
Ecologic or community
Time perspective
Cross-sectional
Enrollment
118
Ages
20 Years to 35 Years
Sex
All
01

Study summary

Anesthesiologists are exposed to substantial occupational stress, making their psychological well-being essential for both personal health and optimal patient care. Early identification of mental health disorders among healthcare professionals is important for improving well-being and maintaining healthcare quality.

Read the detailed description

Although anesthesia residency is associated with considerable psychological stress, residents differ in how they respond to these challenges. While some develop psychological distress, others continue to perform effectively despite the demanding environment. These individuals, often described as "resilient" or "stress resistant," demonstrate successful adaptation to stress. The mechanisms underlying these individual differences remain incompletely understood. As with many aspects of psychological functioning, responses to stress are influenced by the combined effects of genetic predisposition and environmental experiences throughout life.

Among the biological markers investigated in recent years, the second-to-fourth digit (2D:4D) ratio has attracted considerable scientific interest because of its reported associations with a wide range of physical, behavioral, and psychological traits.

02

Conditions studied

  • Anxiety
  • Stress

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Keywords

  • anxiety
  • stress
03

In context

Anxiety Disorders Unverified

7,207 studies on the registry are indexed under Anxiety Disorders; 1,682 are open to participants now.

This study's enrollment of 118 is below the median of 168 across 978 observational studies indexed under Anxiety Disorders.

Browse Anxiety Disorders studies →

Lead sponsor

Ain Shams University is the lead sponsor of 1,953 studies on the registry; 430 are open to participants now.

Of its 35 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Compared within Anxiety Disorders, the registry's first condition term, which may not be this study's main condition. Counted across the registry records on this site, refreshed daily. How we classify →

04

Who can participate

Ages eligible
20 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Anesthesiology residents will be contacted to participate in the study

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Any anesthesiologists who voluntarily agreed to participate in the study.
  • Age: 20-35 years
  • Both genders

Exclusion criteria

Exclusion Criteria:

  • Incomplete questionnaires and/or irrelevant responses.
  • Injuries to the 2nd or 4th digits,
  • Unclear or inaccurate digit photocopy,
  • If the participant is a twin
  • Cumulative leave (e.g., maternity/sick leave) exceeding 6 months during the study period;
  • Pre-existing diagnosis of psychiatric disorders prior to the study
05

Study design

Observational model
Ecologic or community
Time perspective
Cross-sectional
Enrollment
118 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Anxiety score

    Anxiety severity measured using the Penn State Worry Questionnaire (PSWQ). The PSWQ is a 16-item validated measure of the tendency toward excessive, uncontrollable worry, the cognitive hallmark of Generalized Anxiety Disorder. The association between anxiety score and digit measurement will be evaluated. Total scores range from 16 to 80, with higher scores indicating greater worry severity. A score ≥45 is commonly used as a clinical cutoff in research settings, with ≥60 strongly associated with Generalized Anxiety Disorder criteria.

    Time frame: Baseline (single assessment)

Secondary outcomes

  1. Demographic data

    Personal information, habits and health status

    Time frame: Baseline (single assessment)

07

Study locations

1 site
  • Ain Shams University Hospitals
    Cairo, Egypt
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

2 registry updates since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it moved

Ran from Sep 2026 to primary completion in Oct 2026, 0 months.

Primary completion moved twice since we started tracking on Sep 25, 2026: Nov 2026 → Oct 2026, last on Oct 13, 2026.

Completion moved twice since we started tracking on Sep 25, 2026: Dec 2026 → Oct 2026, last on Oct 13, 2026.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Aug 3, 2026
First posted
Aug 11, 2026
StartActual
Sep 10, 2026
Primary completionActual
Oct 2, 2026was Nov 2026
CompletionActual
Oct 9, 2026was Dec 2026
Last update
Oct 13, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Status
Not yet recruiting→Recruiting→Completed
changed Sep 30, 2026 · changed Oct 13, 2026
Sites
1 site added — first site in Egypt
Show site
  • Ain Shams University Hospitals · Cairo, Egypt
Sep 30, 2026
Start date
Sep 15, 2026→Sep 10, 2026 (actual)
Sep 30, 2026
Primary completion
Nov 25, 2026→Oct 2, 2026 (actual)
moved 2 times, Sep 30, 2026 – Oct 13, 2026
Study completion
Dec 30, 2026→Oct 9, 2026 (actual)
moved 2 times, Sep 30, 2026 – Oct 13, 2026
Enrollment
116 (estimated)→118 (actual)
Oct 13, 2026
Show all 2 updates
  1. Oct 13, 2026
    Recruiting→Completed
    Primary completion Oct 15, 2026→Oct 2, 2026 (now actual)
    Study completion Nov 10, 2026→Oct 9, 2026 (now actual)
    Enrollment 116 (estimated)→118 (actual)
    + 4 other changes: identifiers, verification date, contact details and site details
  2. Sep 30, 2026
    Not yet recruiting→Recruiting
    1 site added — first site in Egypt
    Show site
    • Ain Shams University Hospitals · Cairo, Egypt
    Start date Sep 15, 2026→Sep 10, 2026 (now actual)
    Primary completion Nov 25, 2026→Oct 15, 2026
    Study completion Dec 30, 2026→Nov 10, 2026
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07757971
Responsible party
Raham Hasan Mostafa, MD (Professor of Anesthesia ,pain and intensive care, Ain Shams University) — Principal investigator
First posted
Aug 11, 2026
Start date
Sep 10, 2026
Primary completion
Oct 2, 2026
Completion
Oct 9, 2026
Last update
Oct 13, 2026

Study contacts

Raham H Mostafa, MD
principal investigator · Faculty of Medicine, Ain Shams university

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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