ClinicalTrials.gg
Active, not recruitingNCT05035823Updated Sep 8, 2026

COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis

An interventional study of Motor Neuroprosthesis (MNP) in Neurologic Disorder, Paralysis and Paralysis; Stroke, sponsored by Synchron Medical, Inc.. Active, not recruiting at 3 sites in United States. Open to participants aged 21 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-09-08.

Sponsored by Synchron Medical, Inc. · Not applicable, Interventional, and Device feasibility

Phase
Not applicable
Study type
Interventional
Enrollment
6
Allocation
Not applicable
Ages
21 Years to 75 Years
Sex
All
01

Study summary

The Synchron motor neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex. The purpose of this research is to evaluate safety and feasibility.

The MNP is a type of implantable brain computer interface which bypasses dysfunctional motor neurons. The device is designed to restore the transmission of neural signal from the cerebral cortex utilized for neuromuscular control of digital devices, resulting in a successful execution of non-mechanical digital commands.

02

Conditions studied

  • Neurologic Disorder
  • Paralysis
  • Paralysis; Stroke
  • Amyotrophic Lateral Sclerosis
  • Muscular Dystrophies
  • Spinal Cord Injuries
  • Stroke, Lacunar
  • Stroke Brainstem
  • Cervical Spinal Cord Injury
  • Spinal Muscular Atrophy
  • Tetraplegic; Paralysis
  • Quadriplegia/Tetraplegia
03

In context

Nervous System Diseases

757 studies on the registry are indexed under Nervous System Diseases; 218 are open to participants now.

This study's enrollment of 6 is below the median of 55 across 495 interventional studies indexed under Nervous System Diseases.

Browse Nervous System Diseases studies →

Lead sponsor

Synchron Medical, Inc. is the lead sponsor of 2 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
21 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Severe quadriparesis
  2. Able to give consent
  3. Appropriate candidate for neurointerventional procedure
  4. Able and willing to access all clinical testing and not impeded by geographical location
  5. Proficient in English
  6. Have a study partner

Exclusion criteria

Exclusion Criteria:

  1. Active condition resulting in
  2. Unsuitable for general anesthesia
  3. Anaphylactic allergy to contrast media
  4. Allergy to nickel
  5. History of pulmonary embolism
  6. History of recent deep vein thrombosis
  7. Psychiatric or psychological disorder
  8. No study partner or caregiver
  9. Unable to provide evidence of COVID vaccination
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Immunosuppression

A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.

Read whether the line is about a condition or about medicines, and which medicines and doses it means.

05

Study design

Phase
Not applicable
Primary purpose
Device feasibility
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
6 participants (actual)

Study arms

  • Other
    Single

    Implantation of the motor neuroprosthesis medical device.

    Device: Motor Neuroprosthesis (MNP)

Interventions

  • DeviceMotor Neuroprosthesis (MNP)

    Type of implantable brain computer interface

06

What researchers measure

Primary outcomes

  1. Treatment-Related Serious Adverse Events

    Number of subjects with treatment-related adverse events

    Time frame: 12 months post implant

07

Study locations

3 sites
08

References and documents

Publications

  • Chetty N, Kacker K, Feldman AK, Yoo PE, Bennett J, Fry A, Tal I, Hardy NF, Ebrahimi S, Echavarria C, Sawyer A, Schone HR, Harel NY, Nogueira RG, Majidi S, Levy EI, Kandel A, Hill KK, Opie NL, Lacomis D, Collinger JL, Oxley TJ, Putrino DF, Weber DJ. Signal properties and stability of a chronically implanted endovascular brain computer interface. medRxiv [Preprint]. 2025 Sep 25:2025.09.19.25335897. doi: 10.1101/2025.09.19.25335897. PubMed 41040697 ↗
09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Apr 2022 to primary completion in Sep 2024, 28 months.

Of 193 interventional studies with no phase under Nervous System Diseases, half reached primary completion within 30 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 57. This study's 28 months is close to that.

Nervous System Diseases covers many different conditions, not one, so the studies compared here vary widely. Read these figures as a rough guide.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 1, 2021
First posted
Sep 5, 2021
StartActual
Apr 27, 2022
Primary completionActual
Sep 19, 2024
CompletionEst.
Sep 2028
Last update
Sep 8, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 8, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05035823
Lead sponsor
Synchron Medical, Inc.
Responsible party
Sponsor
First posted
Sep 5, 2021
Start date
Apr 27, 2022
Primary completion
Sep 19, 2024
Completion
Sep 2028 (estimated)
Last update
Sep 8, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion