CClinicalTrials.gg
Status unknownNCT05011318FRESHUpdated Mar 23, 2023

Effects of Cognitive Fatigue on Heart Rate Variability and Skin Conductance

An interventional study of Baseline and Fatigue Manipulation in Cognitive Fatigue, Mental Fatigue and Behavioral Performance, sponsored by Nanyang Technological University. Status unknown at 1 site in Singapore. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-03-23.

Sponsored by Nanyang Technological University · Not applicable, Interventional, and Diagnostic

The sponsor has not verified this record recently (last verified Mar 2023), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
162
Allocation
Not applicable
Ages
18 Years to 35 Years
Sex
All
01

Study summary

This study aims to examine the effects of cognitive fatigue on heart rate variability and skin conductance and develop a machine learning model.

Read the detailed description

We hypothesize that increased cognitive fatigue would vary as a function of heart rate variability and skin conductance. A machine learning model will be developed that predicts cognitive fatigue through these physiological responses (Lee et al., 2021). Individual differences (i.e., age, gender, caffeine and food intake, body mass index, skin temperature, sleep quality, baseline physiology and behavioural performance) will be examined and accounted for.

02

Conditions studied

  • Cognitive Fatigue
  • Mental Fatigue
  • Behavioral Performance
  • Heart Rate Variability
  • Skin Conductance
03

In context

Fatigue

1,860 studies on the registry are indexed under Fatigue; 376 are open to participants now.

This study's planned enrollment of 162 is above the median of 54 across 1,440 interventional studies indexed under Fatigue.

Browse Fatigue studies →

Lead sponsor

Nanyang Technological University is the lead sponsor of 48 studies on the registry; 14 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Singapore-based
  • Non-clinical
  • 18-35years

Exclusion criteria

Exclusion Criteria:

  • Individuals with hearing difficulties or failing to meet the minimal threshold for normal hearing
  • Individuals with a history of ear, developmental, neurological, or psychiatric disorder
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
162 participants (estimated)

Study arms

  • Experimental
    Fatigue Manipulation

    Other: Baseline · Other: Fatigue Manipulation

Interventions

  • OtherBaseline

    5-min urban park video clip (Presented on a TV)

  • OtherFatigue Manipulation

    20-min 2-back task (Presented on a computer)

06

What researchers measure

Primary outcomes

  1. 2-Back Task (Change)

    Change in Accuracy over time

    Time frame: during fatigue manipulation

  2. 2-Back Task (Change)

    Change in Reaction Time over time

    Time frame: during fatigue manipulation

  3. Fatigue State Questionnaire

    Fatigue State Questionnaire Score

    Time frame: up to 5 mins after fatigue manipulation

  4. Electrocardiograph (Change)

    Change in Heart Rate Variability over time

    Time frame: during fatigue manipulation

  5. Electrodermal Activity (Change)

    Change in Skin Conductance Level over time

    Time frame: during fatigue manipulation

  6. Electrodermal Activity (Change)

    Change in Skin Conductance Response over time

    Time frame: during fatigue manipulation

07

Study locations

1 of 1 sites recruiting
  • Cultural Science Innovations, Nanyang Technological University
    Singapore, 639798, Singapore
    Recruiting
08

References and documents

Publications

  • Lee KFA, Gan WS, Christopoulos G. Biomarker-Informed Machine Learning Model of Cognitive Fatigue from a Heart Rate Response Perspective. Sensors (Basel). 2021 Jun 2;21(11):3843. doi: 10.3390/s21113843. PubMed 34199416 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 23, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05011318
Lead sponsor
Nanyang Technological University
Collaborators
National Research Foundation, Singapore, Ministry of National Development, Singapore, Housing and Development Board, Singapore
Responsible party
Georgios CHRISTOPOULOS (Associate Professor, Nanyang Technological University) — Principal investigator
First posted
Aug 18, 2021
Start date
Aug 25, 2021
Primary completion
May 15, 2023 (estimated)
Completion
Jun 15, 2023 (estimated)
Last update
Mar 23, 2023

Study contacts

Kar Fye Alvin Lee, PhD
Contact
alvin.lee@ntu.edu.sg
+6591557981
GEORGIOS CHRISTOPOULOS, PhD
Contact
georchris7@gmail.com
+6594898379

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Mar 2023. You cannot join it, but the record below documents what was studied.

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