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Status unknownNCT05002764THALNUC-MSUpdated Aug 12, 2021

Thalamic Nuclei Volumes in Multiple Sclerosis

An observational study in Multiple Sclerosis, sponsored by University Hospital, Bordeaux. Status unknown at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-08-12.

Sponsored by University Hospital, Bordeaux · Observational

The sponsor has not verified this record recently (last verified Aug 2021), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Other
Enrollment
2,000
Ages
18 Years and older
Sex
All
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Study summary

The thalamus is composed of several nuclei interlocked in a complex anatomy. In multiple sclerosis (MS), the thalamus can be altered due to disconnection by white matter lesions and due to direct damages that could be partly mediated by CSF. Due to such pathophysiology and complex anatomy, some nuclei could be more vulnerable to multiple sclerosis than others. We will test this hypothesis by using a new algorithm to automatically segment several nuclei that we will be applied to the French national MS database

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Conditions studied

  • Multiple Sclerosis

Keywords

  • Multiple sclerosis
  • Thalamus
  • Nuclei
  • Atrophy
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In context

Multiple Sclerosis

3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.

This study's planned enrollment of 2,000 is above the median of 100 across 1,016 observational studies indexed under Multiple Sclerosis.

Browse Multiple Sclerosis studies →

Lead sponsor

University Hospital, Bordeaux is the lead sponsor of 783 studies on the registry; 188 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Patients with Multiple Sclerosis and at least one MRI that includes 3D T1 and FLAIR at 1.5T or 3T.

Inclusion criteria

  • Patient older than 18 years old.
  • With Multiple Sclerosis according to Mc Donald 2017 criteria or with clinically isolated syndrome and included with OFSEP cohort.
  • Phenotype known (RR, SP, PP or CIS).
  • Date of diagnosis known.
  • With at least one MRI that includes 3D T1 and FLAIR at 1.5T or 3T.

Exclusion criteria

Exclusion Criteria :

  • Stroke
  • Other causes of dementia not caused by Multiple Sclerosis (Alzheimer's disease, Parkinsonian syndromes...)
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Study design

Observational model
Cohort
Time perspective
Other
Enrollment
2,000 participants (estimated)
Target follow-up
24 Years
Patient registry
Yes
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What researchers measure

Primary outcomes

  1. Volume of thalamic nuclei

    Volume of individual thalamic nuclei according to disease duration.

    Time frame: At inclusion in the cohort

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Study locations

1 of 1 sites recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 12, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05002764
Lead sponsor
University Hospital, Bordeaux
Collaborators
Institut National de la Santé Et de la Recherche Médicale, France
Responsible party
Sponsor
First posted
Aug 12, 2021
Start date
Jul 1, 2021
Primary completion
Jul 1, 2023 (estimated)
Completion
Jul 1, 2023 (estimated)
Last update
Aug 12, 2021

Study contacts

Thomas Tourdias, Pr
Contact
thomas.tourdias@chu-bordeaux.fr
05 56 79 56 04

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2021. You cannot join it, but the record below documents what was studied.

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