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CompletedNCT04865614COMPETENTUpdated Oct 26, 2021

Comparison Between Inhalation and Intravenous Induction of Anaesthesia During Interventional Mitral Valve Repair

An observational study in Blood Pressure and Hypotension Drug-Induced, sponsored by Heidelberg University. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-10-26.

Sponsored by Heidelberg University · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
57
Ages
18 Years and older
Sex
All
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Study summary

The induction of anaesthesia is one of the most critical situations for high-risk-patients undergoing interventions surgery. For several reasons, it is crucial to maintain adequate blood pressure and cardiac output during this phase.

This retrospective cohort study aims to find out if the choice of the induction agent has a major impact on blood pressure and the use of catecholamines during the induction and the interventional procedure in patients undergoing interventional mitral valve repair.

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Conditions studied

  • Blood Pressure
  • Hypotension Drug-Induced

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03

In context

Hypotension

1,003 studies on the registry are indexed under Hypotension; 173 are open to participants now.

This study's enrollment of 57 is below the median of 84 across 294 observational studies indexed under Hypotension.

Browse Hypotension studies →

Lead sponsor

Heidelberg University is the lead sponsor of 279 studies on the registry; 17 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Patients undergoing interventional mitral valve repair

Inclusion criteria

  • Patients undergoing elective interventional mitral valve repair
  • Sevoflurane or etomidate have been used for induction of anesthesia

Exclusion criteria

Exclusion Criteria:

  • Pregnancy
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
57 participants (actual)
Patient registry
No

Groups and cohorts

  • Etomidate group

    Patients who received etomidate for induction of anaesthesia during interventional mitral valve repair (Mitraclip)

    Drug: Etomidate

  • Sevoflurane group

    Patients who received sevoflurane for induction of anaesthesia during interventional mitral valve repair (Mitraclip)

    Drug: Sevoflurane

Interventions

  • DrugEtomidate

    Use of etomidate

  • DrugSevoflurane

    Use of sevoflurane

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What researchers measure

Primary outcomes

  1. Post-induction hypotension

    Hypotension in the first 20 minutes after induction of anesthesia

    Time frame: First 20 minutes after induction of anaesthesia

Secondary outcomes

  1. Use of catecholamines after induction during the first 20 minutes after inductionafter induction

    Use of catecholamines during the first 20 minutes after induction of anaesthesia

    Time frame: First 20 minutes after induction

  2. Use of catecholamines

    Use of catecholamines during the procedure

    Time frame: Length of procedure (Approximately 60 to 90 minutes in average)

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Study locations

1 site
  • Anästhesiologische Klinik (Universitätsklinikum Heidelberg)
    Heidelberg, Baden-Würtemberg 69120, Germany
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 26, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04865614
Lead sponsor
Heidelberg University
Collaborators
University Hospital, Essen
Responsible party
Dr. Adrian Stephan (Principal Investigator, Heidelberg University) — Principal investigator
First posted
Apr 29, 2021
Start date
Apr 1, 2019
Primary completion
Dec 1, 2020
Completion
Dec 1, 2020
Last update
Oct 26, 2021

Study contacts

Adrian E Stephan, MD
principal investigator · Heidelberg University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2021. You cannot join it, but the record below documents what was studied.

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