An interventional study of Hyaluronic acid gel and Hyaluronic acid gel + carrier in Alveolar Osteitis, sponsored by Medical University of Vienna. Status unknown at 1 site in Austria. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2022-09-01.
Sponsored by Medical University of Vienna · Not applicable, Interventional, and Treatment
Alveolar osteitis (AO; syn. dry socket) is one of the most frequent complications following tooth removal and it is defined as presence of severe postoperative pain in and around the extraction site, which increases in severity at any time between one and three days after extraction, accompanied by a partially or completely disintegrated blood cloth within the alveolar socket, with or without halitosis, and at the same time excluding any other cause for the pain (Blum 2002). To enhance standard treatment of AO, which consists of curettage of the dry socket, rinsing with saline solution, and inducing bleeding from the exposed alveolar bone walls, numerous products have been tested. One of them is hyaluronic acid (HY). The aim of the present study is to investigate the potential effect of HY gel application in the treatment of AO. Specifically, the application of HY only (HY test group; n = 20) or the combination of HY and an absorbable collagen sponge (HY+C test group; n = 20) will be compared to standard treatment (blood clot; control group, n=20). Clinical and patient related outcome parameters will be recorded for up to 14 days after treatment. A more stable blood clot and thus improved wound healing with faster pain reduction is expected through the use of HY.
46 studies on the registry are indexed under Dry Socket; 10 are open to participants now.
This study's planned enrollment of 60 is close to the median of 60 across 41 interventional studies indexed under Dry Socket.
Browse Dry Socket studies →Medical University of Vienna is the lead sponsor of 1,109 studies on the registry; 184 are open to participants now.
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Exclusion Criteria:
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An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
hyaluronic acid gel application
Device: Hyaluronic acid gel
hyaluronic acid gel application together with a carrier
Device: Hyaluronic acid gel + carrier
standard treatment (i.e., blood clot only)
After the local anesthesia is injected, alveolar curettage is performed, and the socket is rinsed with saline solution. Prior to wound closure, patients from the test group 1 will receive hyaluronic acid gel.
After the local anesthesia is injected, alveolar curettage is performed, and the socket is rinsed with saline solution. Prior to wound closure, patients from the test group 2 will receive hyaluronic acid gel together with a collagen carrier.
Pain perception by the patient
VAS- Visual analogue scale measured on a 10cm scale, where 0 represents no pain and 10 represents maximum pain
Time frame: 2 weeks
Started May 2021 (actual). Primary completion is estimated for May 2023, 24 months after the start.
Of 22 interventional studies with no phase under Dry Socket, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 24. This study's planned 24 months is above that.
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This study is status unknown, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.
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