An interventional study of Otago Exercise Program and Usual Care in Hip Fractures and Mild Cognitive Impairment, sponsored by University of British Columbia. Completed at 1 site in Canada. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2025-11-24.
Sponsored by University of British Columbia · Not applicable, Interventional, and Prevention
Hip fracture is recognized as one of the most serious consequences of osteoporosis, less than half regain pre-fracture independence. 95% of all hip fractures in older adults are due to falls. Thus, reducing fall risk while restoring function post-hip fracture is critical. Many with fall-related hip fractures have cognitive impairment; cognitive impairment increases the risk of falls. The purpose of this 6-month proof-of-concept randomized controlled trial (RCT) is to assess the efficacy of the home-based Otago Exercise Program (OEP) compared with usual care in reducing fall risk among older adults with mild cognitive impairment (MCI) and a fall-related hip fracture.
Hip fracture is recognized as one of the most serious consequences of osteoporosis, less than half regain pre-fracture independence. 95% of all hip fractures in older adults are due to falls. Thus, reducing fall risk while restoring function post-hip fracture is critical. Many with fall-related hip fractures have cognitive impairment and they are less likely to regain pre-fracture level of function than those without cognitive impairment. Cognitive impairment also increase falls risk. It is currently unknown whether exercise is efficacious in reducing fall risk and promoting function among older adults with mild cognitive impairment (MCI) and a fall-related hip fracture. The purpose of this 6-month proof-of-concept RCT is to assess the efficacy of the home-based Otago Exercise Program (OEP) compared with usual care in reducing fall risk among community-dwelling older adults with MCI and a fall-related hip fracture.
822 studies on the registry are indexed under Hip Fractures; 160 are open to participants now.
This study's enrollment of 60 is below the median of 90 across 529 interventional studies indexed under Hip Fractures.
Browse Hip Fractures studies →University of British Columbia is the lead sponsor of 1,309 studies on the registry; 253 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria: 1) aged 65 or older; 2) sustained a fall-related hip fracture in the last 12 months and have returned home; 3) have preserved general cognition as indicated by a Mini-Mental State Examination (MMSE) score = or > 20/30; 4) have subjective memory complaints, determined by interview;22 5) score \< 26/30 on the Montreal Cognitive Assessment (MoCA); 6) have an absence of significant functional impairment and no dementia as determined by a physician; 7) are not expected to start, or are stable (i.e., > 3 months) on a fixed dose of anti-dementia medications (e.g., donepezil, galantamine) during the RCT; 8) are expected to live > 12 months (based on the geriatricians' expert opinion); 9) can read, write, and speak English with acceptable visual and auditory acuity; 10) are able to walk 3 meters with or without an assistive device; and 1) provide written informed consent.
Exclusion Criteria: 1) diagnosed with or suspected to have (by the geriatrician) a neurodegenerative disease (e.g., Parkinson's disease) or dementia; 2) had a clinical stroke; or 3) have a history indicative of carotid sinus sensitivity (i.e., syncopal falls).
Clinical care provided by geriatricians. Each participant will see the geriatrician at baseline and 6 months.
Other: Usual Care
Clinical care provided by geriatricians. Each participant will see the geriatrician at baseline and 6 months. In addition, they will receive the Otago Exercise Program, an individualized and home-based program of progressive strength and balance training exercises delivered by a physical therapist.
Behavioral: Otago Exercise Program · Other: Usual Care
An individualized and home-based program of progressive strength and balance training exercises delivered by a physical therapist
Also known as: Exercise
Clinical care provided by a geriatrician.
Change in Physiological Profile Assessment
A measure of fall risk (z-score).
Time frame: Baseline to 6 Months
Change in Short Physical Performance Battery
A measure of balance and mobility (out of 12 points).
Time frame: Baseline to 3 Months and 6 Months
Change in Usual Gait Speed
Gait speed over 4 meters (m/s).
Time frame: Baseline to 3 Months and 6 Months
Change in Life Space Assessment
Mobility within a life-space level.
Time frame: Baseline to 3 Months and 6 Months
Change in NIH Cognitive Toolbox
Cognitive performance of executive functions.
Time frame: Baseline to 3 Months and 6 Months
Change in Digit Symbol Substitute Test
Cognitive performance of processing speed.
Time frame: Baseline to 3 Months and 6 Months
Change in Center for Epidemiological Studies Depression Scale
Mood
Time frame: Baseline to 3 Months and 6 Months
Change in Positive and Negative Affect Scale
Mood
Time frame: Baseline to 3 Months and 6 Months
Change in EQ-5D-5L
Quality of Life
Time frame: Baseline to 3 Months and 6 Months
Change in ICE-CAP
Wellbeing
Time frame: Baseline to 3 Months and 6 Months
Change in Physical Activity for the Elderly
Physical activity over the last 7 days
Time frame: Monthly from Baseline to 6 Months
Total Number of Prospective Falls
Self-report of falls using calendars
Time frame: Monthly from Baseline to 6 Months
Change in Activities Specific Balance Confidence
Fall-related self efficacy
Time frame: Baseline to 3 Months and 6 Months
Change in Physiological Profile Assessment
A measure of fall risk (z-score); higher z scores indicate higher risk of falls.
Time frame: Baseline to 3 Months
Change in Timed Up and Go Test
A measure of functional mobility; greater time for completion indicate poorer performance.
Time frame: Baseline to 3 Months and 6 Months
Change in Fried Frailty
A measure of physical frailty
Time frame: Baseline to 3 Months and 6 Months
Change in Clinical Frailty Scale
A measure of frailty; higher value indicate more frailty
Time frame: Baseline to 3 Months and 6 Months
Change in Pittsburgh Sleep Quality Index
A measure of subjective sleep quality
Time frame: Baseline to 3 Month and 6 Months
Change in Rey Auditory Verbal Learning
A measure of episodic memory; higher scores indicate bettter episodic performance.
Time frame: Baseline to 3 Month and 6 Months
This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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University of British Columbia