An interventional study of urinary extracellular vesicle concentration and blood sample in Chronic Renal Failure and Urinary Extracellular Vesicle, sponsored by Centre Hospitalier Universitaire, Amiens. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-19.
Sponsored by Centre Hospitalier Universitaire, Amiens · Not applicable, Interventional, and Other
The recent discovery of extracellular vesicles (EV) as a mechanism of intercellular communication has made it possible to develop a new field of health research and could bring new information on the pathological mechanisms of renal diseases. Definition of physiologic and pathologic values of urinary extracellular vesicles (EVu) between healthy subjects and chronic kidney diseases (CKD) patients could be a new tool for follow up of renal diseases. EV are found in all biological fluids including urine, that's why they are increasingly analyzed in renal pathologies. The main objective of this study is to determine the physiological values and the pathological thresholds of EVu.
2,085 studies on the registry are indexed under Kidney Failure, Chronic; 260 are open to participants now.
This study's enrollment of 143 is above the median of 55 across 1,557 interventional studies indexed under Kidney Failure, Chronic.
Browse Kidney Failure, Chronic studies →Centre Hospitalier Universitaire, Amiens is the lead sponsor of 576 studies on the registry; 178 are open to participants now.
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Exclusion Criteria:
healthy subjects : no medical history, in particular cardiovascular, without drug treatment, without proteinuria, normal BMI
Diagnostic Test: urinary extracellular vesicle concentration · Diagnostic Test: blood sample
CRF patients : eGFR estimated according to the MRDR formula less than 89 mL/min/1,73m²
Diagnostic Test: urinary extracellular vesicle concentration · Diagnostic Test: blood sample
urinary extracellular vesicle concentration will be determined in urine samples from CRF and healthy patients
blood sample in order to determine creatin level
variation of urinary extracellular vesicle concentration between both groups
variation of urinary extracellular vesicle concentration between both groups : healthy and CRF patients Urinary extracellular vesicle concentrations will be measured as number of extracellular vesicles per mL of urine
Time frame: one day
Plan to share: No
This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire, Amiens