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CompletedNCT04691479PIMA1-JO-PRUpdated Dec 31, 2020

Adherence and Quality of Life of CPAP for Obstructive Sleep Apnea

An interventional study of Motivational Interview (MI) & Adherence Follow-Up and Adherence Follow-Up in Sleep Apnea, Obstructive, sponsored by Air Liquide Healthcare Spain. Completed at 1 site in Spain. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-12-31.

Sponsored by Air Liquide Healthcare Spain · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
129
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

A multicentre, randomized controlled trial (RCT) design.The control group followed the usual treatment, while the intervention group (PIMA) followed the treatment with an adapted and flexible care plan depending on socio-demographic, clinical and psychological variables. The treatment plan includes different channels (home, telephone, care center), a continuous evaluation, and the use of the motivational interview in each of the interventions with the patient. The main outcome was adherence. Secondary outcomes were quality of life, emotional state, activities, social relationships, perceived competence and motivation.

Read the detailed description

The aim of this trial was to determine adherence to CPAP and health- related outcomes in patients with OSA via a comprehensive and multidisciplinary program based on stratification and individualized care plans, including the motivational interview.

A multicentre, randomized controlled trial (RCT) design was used. The control group followed the usual treatment, while the intervention group (PIMA) followed the treatment with an adapted and flexible care plan depending on socio-demographic, clinical and psychological variables. The treatment plan includes different channels (home, telephone, care center), a continuous evaluation, and the use of the motivational interview in each of the interventions with the patient. The main outcome was adherence. Secondary outcomes were quality of life, emotional state, activities, social relationships, perceived competence and motivation.

02

Conditions studied

  • Sleep Apnea, Obstructive

Keywords

  • CPAP
  • Sleep Apnea
  • Adherence
  • Quality of Life
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Older than 18 years
  • Diagnosis of OSA confirmed by sleep studies with polygraphy (PS) and / or polysomnography (PSG)

Exclusion criteria

Exclusion Criteria:

  • Subjects with obesity-related hypoventilation
  • Severe COPD (chronic obstructive pulmonary disease)
  • Cognitive disorders and those unable to understand the consent to participate
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
129 participants (actual)

Study arms

  • Experimental
    PIMAGroup

    1. Educational and training program using motivational interview technical. 2. Stratification labels: to determine the personalized intervention plan are obtained from two types of variables: personal and modulation variables. For psychological variables the Perceived Competence Evaluation Questionnaire validated in Adherence to CPAP in OSA (CEPCA) is used. Drowsiness is obtained through the administration of the Epworth Somnolence Test, and the apnoea-hypopnea index is taken from the patient's clinical history. 3. Segmentation: With the psychological and clinical variables, in this first visit, "predictive" information is obtained on how the patient's adherence will be: high adherence, moderate adherence or low adherence. 4. Taking this information into account, the care plan will start considering how the patient is and their situation with respect to adherence. Depending on their evolution, the care plan is adapted. For patients with low adherence, telemonitoring is used.

    Behavioral: Motivational Interview (MI) & Adherence Follow-Up

  • Experimental
    Control

    The patients followed the standard of care, which consists of starting therapy in the hospital, where the nurse performed training in the use of CPAP equipment, mask adjustment, and safety and maintenance instructions. For follow-up, the patient was always referred to the Hospital, with a frequency established by the Spanish Society of Pulmonology and Thoracic Surgery (Day 30, Day 90 and Day 180). The follow-up procedure consisted of reviewing the CPAP hour meter and resolving any incidents that may have arisen, with the necessary corrective actions (change of mask, positive reinforcement, and explanation of specific aspects).

    Behavioral: Adherence Follow-Up

Interventions

  • BehavioralMotivational Interview (MI) & Adherence Follow-Up

    1. MEntA: Educational \& Training Program 2. Stratification: Identification of Personal Variables (Age, Level of study, Work status, preference of care attention, digital behaviour) 3. Adherence evaluation: Evaluation of Perceived Competence, Quality of Life, Mood, Activities, Social relations and Social Support 4. Identification of Care plan and Schedule next visits 5. Follow-up D30-D60-D90-D180 depending of the care plan, through the channel that belong for each care plan

  • BehavioralAdherence Follow-Up

    The nurse takes the compliance of the CPAP device, and ask to the patient if he had some problems.

05

What researchers measure

Primary outcomes

  1. Adherence (changes)

    Number of hours of use of CPAP per night

    Time frame: Day 90, Day 180

  2. Somnolence (changes)

    Residual sleepiness after use of CPAP. Epworth Sleepiness Scale. Minimum score: 0; Maximum: 24. Higher scores=worse outcome

    Time frame: Day 1, Day 90, Day 180

  3. Perceived Competence (changes)

    Self-Efficacy in the CPAP treatment. Perceived Competence Evaluation Questionnaire. Minimum score: 0; Maximum score 13. Higher score= Better outcome.

    Time frame: Day 1, Day 90, Day 180

Secondary outcomes

  1. Quality of Life (Changes)

    Well-Being of the patient related to sleep apnea. Analogical Well-Being in Sleep Apnea Scale. Mininum score: 0; Maximum score: 10. Higher score= better outcome.

    Time frame: Day 1, Day 90, Day 180

  2. Mood (Changes)

    Emotional status related to sleep apnea. Ad hoc question. Minimum score: 0; maximum score: 3. Higher score: Better outcome.

    Time frame: Day 1, Day 90, Day 180

  3. Activities (Changes)

    Improving general activity after use CPAP. Ad hoc question. Minimum score: 0; maximum score: 3. Higher score: Better outcome.

    Time frame: Day 1, Day 90, Day 180

  4. Social Relations (Changes)

    Improving general social relations after use CPAP. Ad hoc question. Minimum score: 0; maximum score: 3. Higher score: Better outcome.

    Time frame: Day 1, Day 90, Day 180

06

Study locations

1 site
  • David Rudilla
    Madrid, 28020, Spain
07

References and documents

Study documents

  • Protocol, analysis plan and consent form · Feb 14, 2018

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: Yes — Publication of results in two phases: * National Congress in Portugal * Publication in Research Journal

Supporting information: Study protocol, Sap, Icf, Csr

08

Registry details

Key details

Study ID
NCT04691479
Lead sponsor
Air Liquide Healthcare Spain
Collaborators
Hospital Universitari Joan XXIII de Tarragona., Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Responsible party
Sponsor
First posted
Dec 31, 2020
Start date
Mar 10, 2018
Primary completion
Sep 11, 2018
Completion
Nov 20, 2018
Last update
Dec 31, 2020

Study contacts

Pedro Landete, PhD
principal investigator · Fundación de Investigación Biomédica - Hospital Universitario de La Princesa

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
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