An interventional study of blood sample tests for determination of biomarkers levels in Aortic Aneurysm, Thoracoabdominal Aneurysm and Aortic Dissection, sponsored by Petrovsky National Research Centre of Surgery. Completed at 1 site in Russian Federation. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2024-09-19.
Sponsored by Petrovsky National Research Centre of Surgery · Not applicable, Interventional, and Basic science
Biomarkers can play a vital role in prognosing the perioperative complications in thoracic aorta surgery. The goal of a study is to determine the correlation between intraoperative level of certain biomarkers and total amount of peroperative complications.
This study aims to assess the association between levels of biomarkers and postoperative complications in patients after thoracic and thoracoabdominal aortic reconstruction.
960 studies on the registry are indexed under Aneurysm; 175 are open to participants now.
This study's enrollment of 132 is above the median of 72 across 462 interventional studies indexed under Aneurysm.
Browse Aneurysm studies →Petrovsky National Research Centre of Surgery is the lead sponsor of 18 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Blood samples on proadrenomedullin, presepsin, NT-proBNP, Troponin I, procalcitonin are acquired
Diagnostic Test: blood sample tests for determination of biomarkers levels
Using of proadrenomedullin, presepsin, NT-proBNP, Troponin I to determine the correlation of perioperative complications.
Number of Total Postoperative Complications
Value reported in the Outcome Measure data table reflects the Number of Total Postoperative Complications across all participants.
Time frame: up to 10 days
Total Number Affected by All-Cause Mortality
Overall number of participants, in each arm/group, who died due to any cause
Time frame: up to 10 days
Number of Participants Who Require Extracorporeal Detoxication
Time frame: up to 10 days
Number of Cardiac Disorders
Number of patients who needed medicamental cardiotonic support more than 1 day
Time frame: up to 10 days
Number of Vascular Disorders
Number of patients who needed vasopressor support more than 1 day
Time frame: up to 10 days
Number of Infections and Infestations
Number of patients who develop systemic infection and/or operation wound infection
Time frame: up to 10 days
| Milestone | Thoracic Aorta Surgery Patients |
|---|---|
| Started | 132 |
| Completed | 132 |
| Not completed | 0 |
Value reported in the Outcome Measure data table reflects the Number of Total Postoperative Complications across all participants.
| post-operative complications | Thoracic Aorta Surgery Patients |
|---|---|
| Number of Total Postoperative Complications | 69 |
Overall number of participants, in each arm/group, who died due to any cause
| Participants | Thoracic Aorta Surgery Patients |
|---|---|
| Total Number Affected by All-Cause Mortality | 2 |
| Participants | Thoracic Aorta Surgery Patients |
|---|---|
| Number of Participants Who Require Extracorporeal Detoxication | 7 |
Number of patients who needed medicamental cardiotonic support more than 1 day
| Participants | Thoracic Aorta Surgery Patients |
|---|---|
| Number of Cardiac Disorders | 16 |
Number of patients who needed vasopressor support more than 1 day
| Participants | Thoracic Aorta Surgery Patients |
|---|---|
| Number of Vascular Disorders | 14 |
Number of patients who develop systemic infection and/or operation wound infection
| Participants | Thoracic Aorta Surgery Patients |
|---|---|
| Number of Infections and Infestations | 36 |
Collected over Up to 10 days postoperative. Non-serious events are listed at a 5% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Thoracic Aorta Surgery Patients | 2/132 (1.5%) | 41/132 (31.1%) | 24/132 (18.2%) |
| Event | Thoracic Aorta Surgery Patients |
|---|---|
| PneumoniaInfections and infestations | 29/132 |
| Patients requiring extracorporeal detoxicationRenal and urinary disorders | 7/132 |
| Myocardial infarctionCardiac disorders | 5/132 |
| Event | Thoracic Aorta Surgery Patients |
|---|---|
| Cardiac dysrhythmiasCardiac disorders | 24/132 |
| Age, Continuous(years) | Thoracic Aorta Surgery Patients |
|---|---|
| Mean | 56 ± 13 |
| Sex: Female, Male(Participants) | Thoracic Aorta Surgery Patients |
|---|---|
| Female | 45 |
| Male | 87 |
| Race (NIH/OMB)(Participants) | Thoracic Aorta Surgery Patients |
|---|---|
| American Indian or Alaska Native | 0 |
| Asian | 0 |
| Native Hawaiian or Other Pacific Islander | 0 |
| Black or African American | 0 |
| White | 132 |
| More than one race | 0 |
| Unknown or Not Reported | 0 |
| Region of Enrollment(Participants) | Thoracic Aorta Surgery Patients |
|---|---|
| Russia | 132 |
| Body surface area, м²(square meters) | Thoracic Aorta Surgery Patients |
|---|---|
| Mean | 2 ± 0.22 |
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Plan to share: No
This study is completed, as verified in Aug 2024. You cannot join it, but the record below documents what was studied.
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Petrovsky National Research Centre of Surgery