An interventional study of adjunctive bright white light therapy in the morning and adjunctive bright white light therapy in the afternoon in Depressive Disorder and Light Therapy, sponsored by Guangzhou Psychiatric Hospital. Status unknown at 1 site in China. Open to participants aged 12 Years to 75 Years. Per ClinicalTrials.gov, last updated 2021-03-23.
Sponsored by Guangzhou Psychiatric Hospital · Not applicable, Interventional, and Treatment
Among 54 studies in Depressive Disorder with a site in China — 21 open to participants now, 23 under way, 2 of them phase 3. Depressive Disorder · China.
Among the 54 studies in Depressive Disorder with a site in China, this one is the 18th largest by planned enrollment of the 42 interventional ones, is one of 3 that started in 2021, is one of 28 with no phase, and was the 22nd registered.
855 studies on the registry are indexed under Depressive Disorder; 159 are open to participants now.
This study's planned enrollment of 159 is above the median of 88 across 689 interventional studies indexed under Depressive Disorder.
Browse Depressive Disorder studies →21 of the 54 studies in Depressive Disorder with a site in China are open now, in 12 countries. Each count lists the studies.
Of the 115 Depressive Disorder studies recruiting now, 43 (37%) set no upper age limit and 66 (57%) stop at 75 or younger; 24 take children under 18; 25 take healthy volunteers.
This study: 12 Years to 75 Years · all sexes · no healthy volunteers.
The full table on the hub →54 studies; the count open now beside each. This study's row is marked.
First in 2006; this study’s year is marked. 3 started in 2021.
Median enrollment 120 across the 42 interventional studies, 180 across the 12 observational. Of the 18 that completed or were terminated, 1 (6%) have results posted.
5 of 54 have an industry lead sponsor. The 10 most frequent:
Guangzhou Psychiatric Hospital is the lead sponsor of 13 studies on the registry; 2 are open to participants now.
Guangzhou Psychiatric Hospital has 2 studies filed under Depressive Disorder — fewer than ten, so there is no comparison to draw.
5 of the studies in Depressive Disorder with a site in China that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05095662Shanghai Mental Health CenterEstablish a Specific Cohort Database for Depressive Disorders | 2026-12-31 |
| NCT07290153Fudan UniversityPsychological State, Immunotherapy Response, and Multi-Omics Signatures in TNBC | 2027-06-30 |
| NCT07813169Guo WenbinStudy on iTBS Regulating the Reward Circuit Function to Improve Anhedonia in Depression | 2027-07-03 |
| NCT07639476Beijing HuiLongGuan HospitalStudy on Mental Health Promoting Effects of Natural Psychotherapy for Adolescents | 2027-07-31 |
| NCT07252427Fang TangGut Microbiota in IBD With Comorbid Depressive Disorder | 2027-11-30 |
Among the 54 studies in Depressive Disorder with a site in China, from their registry updates:
The study would enroll depressed adolescents and adults with bipolar I or II disorder or major depressive disorder who are receiving stable psychiatric medication (excluding patients with hypomania or mania, mixed symptoms, or rapid cycling). Participants would be randomly assigned to treatment with either 1,0000-lux bright white light therapy in the morning or 1,0000-lux bright white light therapy in the afternoon, or \<100-lux dim red placebo light therapy in the afternoon (N=59 for each group). Participants would be treated for 6 weeks. Symptoms would be assessed every two weeks with the 24-items Hamilton Depression Scale, the Young Mania Rating Scale, and the Pittsburgh Sleep Quality Index; salivary melatonin and cortisol concentrations will be also measured.
The investigators would divide the participants enrolled into three groups: adjunctive morning bright light therapy (BLT) group (light intensity: 10000lux, color: white light, duration of each intervention session: 30min, time period of intervention: 7:00\~9:00 a.m.), adjunctive afternoon BLT group (light intensity: 10000lux, color: white light, duration of each intervention session: 30min, time period of intervention: 12:00\~14:00 p.m.), adjunctive placebo therapy group (light intensity: \<100lux, color: dark red, duration of each intervention session: 30min, time period of intervention: 12:00\~14:00 p.m.).
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
treat participants with adjunctive BLT in the morning
Device: adjunctive bright white light therapy in the morning
treat participants with adjunctive BLT in the afternoon
Device: adjunctive bright white light therapy in the afternoon
treat participants with adjunctive dim red light in the afternoon
Device: adjunctive dim red light therapy in the afternoon
the participants would receive adjunctive bright white light therapy in the morning (light intensity: 10000lux, color: white light, duration of each intervention session: 30min, time period: 7:00\~9:00) for 6 weeks.
the participants would receive adjunctive bright white light therapy in the afternoon (light intensity: 10000lux, color: white light, duration of each intervention session: 30min, time period: 12:00\~14:00) for 6 weeks.
the participants received dim red light therapy (light intensity: \<100lux, color: dark red, duration of each intervention session: 30min, time period: 12:00\~14:00) for 6 weeks.
response rate
Participants with a decrease in 24-items Hamilton Depression Scale (HDRS) score of 50% or more from baseline. HDRS is used to measure the depressive severity；its measured time range is within the past week. In this study, version of 24-items is used. The patients are depressed when the total score are greater than 19 points, and there are no depression when the total scores are less than points.
Time frame: up to week 6
manic/hypomanic conversion rate
The Young Mania Rating Scale (YMRS) is used to assess manic/hypomanic symptoms and their severity; its measured time range is within the past week. The higher the score, the more severe the symptom. If the total score is greater than or equal to 20, manic episode is considered; if the total score is less than 6, it means there is no manic/hypomanic symptoms.
Time frame: week 2; week 4; week 6
side effect
record the possible adverse reactions
Time frame: week 2; week 4;week 6
sleep quality
Pittsburgh Sleep Quality Index (PSQI) is used to evaluate sleep quality for last month. It's made of 7 items; every item is scored 1-4 point. Total score is obtained by adding up the points of 7 items. Total score range is 0\~21 point. The sleep quality is worse when the total score is higher.
Time frame: week 2; week 4;week 6
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Mar 2021; primary completion for May 2022, 14 months later.
Of 260 non-industry interventional studies with no phase under Depressive Disorder, half reached primary completion within 29 months of starting (the median), counting those still running; a quarter within 15 and three quarters within 46. This study's planned 14 months is below that.
Counting every sponsor, half of 274 studies reached it within 29 months; a quarter within 15 and three quarters within 46.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Feb 2021. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Guangzhou Psychiatric Hospital