An observational study in Psoriatic Arthritis, Psoriasis and Non-Inflammatory Rheumatic Conditions, sponsored by Women's College Hospital. Completed at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-05-14.
Sponsored by Women's College Hospital · Observational
Psoriatic arthritis (PsA) is a type of joint disease that can lead to severe joint damage and disability within the first few years of the disease. This is why early detection and treatment of the disease is essential to prevent serious joint damage and improve long-term outcomes in these patients. However, there is currently no reliable way to tell the difference between PsA and other types of joint disease. This makes it difficult to detect PsA early. Enthesitis is an inflammation of the area where muscle tendons and ligaments attach to bones. Enthesitis is a key feature in PsA and can be easily detected using ultrasonography. The aim of this research study is to develop a system to evaluate enthesitis using ultrasonography, which can be used as an effective tool in the early detection of PsA. This will help in providing patients with early treatment to prevent further joint damage.
3,554 studies on the registry are indexed under Arthritis; 317 are open to participants now.
This study's enrollment of 419 is above the median of 155 across 1,057 observational studies indexed under Arthritis.
Browse Arthritis studies →Women's College Hospital is the lead sponsor of 83 studies on the registry; 20 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Study subjects will be recruited form rheumatology and dermatology clinics at participating recruitment sites throughout the world.
General Inclusion Criteria:
Specific Inclusion Criteria for PsA:
Specific Inclusion Criteria for Psoriasis:
Specific Inclusion Criteria for non-inflammatory rheumatic disease:
Exclusion Criteria:
Subjects newly diagnosed with psoriatic arthritis (\< 5 years), confirmed by a rheumatologist and fulfilling the ClASsification for Psoriatic ARthritis (CASPAR) criteria.
Diagnostic Test: Musculoskeletal Ultrasound
Patients with dermatologist confirmed psoriasis, without any history of Psoriatic Arthritis, and musculoskeletal symptoms.
Diagnostic Test: Musculoskeletal Ultrasound
Patients with non-inflammatory rheumatic conditions such as osteoarthritis, non-specific back pain, soft tissue rheumatism, degenerative tendinopathy and fibromyalgia. Patients with present or past history of psoriasis, psoriatic arthritis, known or suspected rheumatic inflammatory conditions (e.g. rheumatoid arthritis, spondyloarthritis and gout), and/or inflammatory bowel disease will be excluded.
Diagnostic Test: Musculoskeletal Ultrasound
High quality ultrasound scanners and high-resolution transducers, will be used to scan 16 joints sites for each subject. Ultrasound had excellent spatial resolution, making it an highly efficient, non-invasive tool for the assessment on enthesitis, which is an early feature of psoriatic arthritis. It is an affordable and accessible tool that is widely used in rheumatology practice.
DUET scoring system for early diagnosis of PsA
To derive the DUET scoring system for distinguishing PsA from non-inflammatory disease using musculoskeletal ultrasound. The investigators will report the optimal set of weighted parameters and their performance measures (area under the curve, suggested cut-off points, sensitivity, and specificity).
Time frame: From beginning to end of physical & ultrasound assessment, up to 1.5 hours
Assess the construct validity of the new DUET scoring system
Construct validity of the newly derived DUET scoring system will evaluate its correlation with clinical measures of disease activity (e.g. total enthesitis count, joint count) and patient reported outcomes. The investigators will evaluate the agreement between central and local readers using the new scoring system to evaluate its reliability among local readers using intra-class correlation coefficient.
Time frame: From beginning to end of physical & ultrasound assessment, up to 1.5 hours
Plan to share: Undecided
This study is completed, as verified in May 2024. You cannot join it, but the record below documents what was studied.
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