An observational study in Covid19, sponsored by Lahore General Hospital. Completed at 1 site in Pakistan. Open to participants aged 20 Years to 60 Years. Per ClinicalTrials.gov, last updated 2022-02-15.
Sponsored by Lahore General Hospital · Observational
This study is about the current knowledge on the immunological changes observed in various healthcare workers in this part of the world, who remained asymptomatic while working in high exposure areas of COVID-19 infection.
Coronaviruses (CoVs) are enveloped, single positive-strand RNA viruses belonging to the large subfamily Coronavirinae, which can infect mammals and several other animals.The continued spread of coronavirus disease 2019 (COVID-19) has prompted widespread concern around the world, and the World Health Organization (WHO), on 11 March 2020, declared COVID-19 a pandemic. Studies on severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) showed that virus-specific antibodies were detectable in 80-100% of patients at 2 weeks after symptom onset. Currently, the antibody responses against SARS-CoV-2 remain poorly understood and the clinical utility of serological testing is unclear. Little is known about the kinetics, tissue distribution, cross-reactivity and neutralization antibody response in COVID-19 patients. Asymptomatic cases are common but to date there are scarce epidemiological surveys that provide a clear percentage of asymptomatic cases.
A large number of healthcare workers have been infected with the virus worldwide, presenting with severe symptoms to no symptoms at all, in which case being diagnosed on contact tracing only. The seropositivity rate in previously undiagnosed healthcare workers has been reported in different regions of the world. In a combined study of three hospitals of Turkey, the seropositivity rate of the previously undiagnosed HCWs was 2.7%. A study done in China revealed 17.5 % seropositivity rate.
This study will aim to comprehensively review the current knowledge on the immunological changes observed in various healthcare workers in this part of the world, who remained asymptomatic while working in high exposure areas of COVID-19 infection.
7,775 studies on the registry are indexed under COVID-19; 482 are open to participants now.
This study's enrollment of 970 is above the median of 260 across 3,188 observational studies indexed under COVID-19.
Browse COVID-19 studies →Lahore General Hospital is the lead sponsor of 30 studies on the registry; 4 are open to participants now.
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Healthcare workers who have been working in high exposure areas of COVID 19 and havenot developed disease themselves while working in that area
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Exclusion Criteria:
All healthcare workers who worked in high exposure areas of hospital dealing with COVID 19.
Diagnostic Test: IgG SARS CoV 2 antibodies
The asymptomatic healthcare workers of high exposure COVID19 areas will be tested for IgG SARS CoV 2 antibodies
SARS CoV 2 IgG antibodies
The presence or absence of SARS CoV 2 antibodies in serum of HCWs
Time frame: 3 months
Plan to share: Undecided
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This study is completed, as verified in Feb 2022. You cannot join it, but the record below documents what was studied.
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Lahore General Hospital